【摘要】本综述重点介绍新的房颤药物治疗策略，包括：1)特异抑制心房IKur、IK-ACh或INa的药物；2)影响非离子通道的上游治疗；3)原有的抗房颤药物安全性改进后的新药；4)在不影响钠通道的情况下改善传导的G连接治疗。

    【关键词】心房颤动；抗心律失常药物；电生理学

    New pharmacological strategies for the treatment of aerial fibrillation WANG Jing, Tianjin people’s hospltal.

    【Abstract】 This review focuses on new pharmacological approaches under investigation for the treatment of AF，Including：1)Agents that produce atrial specific or predominant inhibition of IKur, IK-Ach or INa; 2) “Upstream therapies” ; 3) Derivatives of “old” anti-AF drugs with an improved safety pharmaclolgical profile; and 4) Gap junction therapy aimed at improving conduction without affecting sodim channels.

    【Key words】Atrial fibrillation；Antiarrhythmic drugs；Electrophysiology

    心房颤动(简称房颤)是临床上常见的心律失常 ......