华蟾素联合化疗治疗晚期恶性肿瘤56例疗效分析
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【摘要】 目的：观察华瞻素联合化疗治疗恶性肿瘤的疗效。方法：经病理确诊的晚期恶性肿瘤患者56例, 随机分为两组。治疗组28 例, 采用华蟾素联合化疗; 对照组28 例, 应用单纯化疗。结果：治疗组CR 4例、PR 11 例、CR + PR 为53.57 % (15/28)。对照组CR 2 例, PR 10例, CR+PR 为42.85 % (12/28)。治疗组静脉炎发生率及生活质量高于对照组, 但消化道反应及骨髓抑制率均低于对照组。结论：华蟾素配合化疗治疗恶性肿瘤效果明显, 且安全可靠,值得临床推广。
【关键词】 华蟾素；肿瘤；药物疗法
Aanlysis of the therapeutic effects of cinobufotal in combined w ith chemotherapy for advanced m alignant tumors with 56 cases
Xu Xiao YingLi Xiu RongLi Na Li Guo Quan
(The second Affiliated Hospital of Da Lian Medical University on radiotherapy，in Da Lian,116027)
【Abstract】Objective：To evaluate the therapeutic effects of cinobufotalin combined with chemo therapy for advanced m alignant tumors. Methods：48 cases of advanced m alignant tumor pat ients were treated during 2007, 5 to2009, 3. They were divided at random into 2 groups: Therapy group 28 cases, using cinobufotalin combined with chemotherapy and control group 28 cases, using chemotherapy alone. The therapeutic effects and the side reactions were compared. Results：In the therapy group. 4 cases showed complete response (CR ) and 11 cases of partial response (PR). The total response rate as 53.57 % , while in the control group , there were only 2 case of complete response and 10 cases of partial response, CR+ PR w as 42.85 %.Aomong the side react ions, phlebit and life quality in the therapy group were hihger than that of the control group , while digestive system reactions of digestive system and bone marrow depression were less than contol group. Conclusion：The use of cinobufotalin combined with chemotherapy is a safe and reliable treatment for advanced m alignant tumors.
【Key words】Cinobufotalin；Neop lasm s；Durgtherapy
华蟾素是利用现代制药技术从中华大蟾蜍体内提取的一种水溶性注射液, 具有抗肿瘤和免疫促进等作用。作者自2007年5 月开始应用华蟾素联合化疗治疗28 例晚期恶性肿瘤患者, 取得了较好的近期疗效, 并与单纯应用化疗的28例同期患者比较, 现报告如下。
材料与方法
1临床资料
自2007 年5 月~2009 年3 月间治疗观察可供分析的56 例晚期癌症患者, 均经病理确诊, Karnofsky (KPS) 评分平均50 分;白细胞计数4.0×109/L 以上、血小板计数100×109/.L 以上; 肝、肾及心功能正常, 估计生存6个月以上者, 随机分为两组。治疗组28 例，其中男17例，女11例；年龄45~76岁，中位年龄58 岁；其中食管癌5 例，肺癌9 例，胰腺癌8例，胃癌6例；对照组28 例，其中男15 例，女13 例；年龄42~74 岁 ，平均年龄59 岁；其中胃癌6 例，肺癌15例，食管癌7例；两组患者的年龄、性别及病理分型无统计学差异 ......
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