脑钠肽定量分析充血性心力衰竭治疗效果(1)
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【摘要】 目的动态测定脑钠肽(BNP)水平，定量分析卡托普利联合倍他乐克方案治疗充血性心力衰竭的疗效，探讨BNP指标在充血性心力衰竭患者疗效评估中的敏感及稳定性。 方法选取确诊为充血性心衰病人80例，分别测定每例病人治疗前、治疗后一周、一个月及3个月的NYHA心功能分级、BNP水平及左室射血分数(LVEF)，对每例病人不同时段的疗效差别进行统计分析。 结果在卡托普利联合倍他乐克方案治疗充血性心力衰竭的第一周﹑第一个月及第三个月血浆BNP水平的改变幅度(定义为疗效)与LVEF值的改变幅度(定义为疗效)的差别经统计学分析，结果无统计学意义(P>0.05)；在慢性充血性心力衰竭药物治疗后的第一周，BNP与NYHA心功能分级的改变幅度(定义为疗效)差异具有统计学意义(P<0.05)，而在治疗后的第一及第三个月时两指标改变幅度(定义为疗效)的差异经统计学分析，结果无统计学意义(P>0.05)。 结论动态测定BNP水平在充血性心力衰竭疗效的定量分析中具有较高的敏感及稳定性，是一种可用于充血性心力衰竭早期疗效评估的可靠工具。
【关键词】脑钠肽；卡托普利；倍他乐克；疗效
Using brain natriuretic peptide to quantitatively analyse the therapeutic effect of congestive heart failure
【Abstract】ObjectiveQuantitatively analysing the therapeutic effect of congestive heart failure treated by scheme of captopril combining with metoprolol by brain natriuretic peptide(BNP) dynamic measuring to explore the sensitivity and constancy of BNP in evaluating the therapeutic effect of congestive heart failure.Methods80 patients made a definite diagnosis of congestive heart failure were selected and whose cardiac functional grading of NYHA,BNP and left ventricular ejection fraction(LVEF) were determined respectively pre-treatment, one week, one month and three months later pro- treatment.Statistical analysis on the difference of therapeutic effect was performed for each case. ResultsNo statistically significant was found between the amplitude of BNP and LVEF in one week and on one month, three months pro- treatment by the scheme of captopril combining with metoprolol(P>0.05). But between the BNP and the cardiac functional grading, statistically significant was found in the fitst week pro-treament(P<0.05) ,when on one month and three months after treatment the statistically significant still not found(P>0.05). ConclusionBNP dynamic measuring had the hige sensitivity and constancy in quantitatively analysing the therapeutic effect of congestive heart failure which could be treated as a reliable tool for evaluating the therapeutic effect of congestive heart failure.
【Key word】brain natriuretic peptide, captopril, metoprolol, therapeutic effect
心衰是多种因素导致的心功能不全的一种临床综合征，是多种心脏病的严重阶段，发病率高，总体预后较差，有效的治疗对于改善该类患者的预后﹑降低其死亡率具有重要意义 ......
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