【摘要】目的：探讨四联疗法治疗幽门螺旋杆菌感染(Hp) 相关性消化性溃疡(PU)的疗效。方法：162例幽门螺杆菌阳性的消化性溃疡患者，随机分为治疗组82例及对照组80例。治疗组给予奥美拉唑+甲硝唑+阿莫西林+海洋胃药联合用药方案;对照组用西咪替丁+甲硝唑+阿莫西林+海洋胃药进行治疗,并观察其疗效。结果：治疗组与对照组Hp根除率分别为87.9%、90.5%，差异无显著性(P>0.05);4周后溃疡愈合总有效率分别为95.12%和88.75%，差异有显著性(P<0.05)。结论：奥美拉唑、甲硝唑、阿莫西林、海洋胃药四联疗法具有疗程短、疗效高、值得基层医院推广应用。

    【关键词】消化性溃疡 幽门螺旋杆菌 奥美拉唑 阿莫西林 甲硝唑 海洋胃药

    【Abstract】Objective: To investigate the quadruple therapy for Helicobacter pylori infection (Hp)-related peptic ulcer (PU) of the patients. Methods: 162 cases of Helicobacter pylori positive peptic ulcer patients, 82 cases were randomly divided into treatment group and control group 80 cases. The treatment group received omeprazole + metronidazole + amoxicillin + sea combined regimen stomach; control group, cimetidine + metronidazole + amoxicillin for treatment of marine stomach, and observe its effect. Results: The Hp eradication rate and the control group were 87.9%, 90.5%, the difference was not significant (P> 0.05); 4 weeks after the total effective rate of ulcer healing was 95.12% and 88.75%,There was a significant difference (P <0.05). Conclusions: Omeprazole, metronidazole, amoxicillin, quadruple therapy with marine stomach short course of treatment, efficacy, should promote the use of primary hospital. ......