【摘要】目的 探讨妊娠期肝内胆汁淤积症(ICP)对母体和新生儿的影响。方法 回顾性分析我院53例妊娠期肝内胆汁淤积症孕妇的临床资料，同时对同期正常孕妇60例临床资料进行分析，比较母体和围生儿结局。结果 ICP组孕妇剖宫产、产后出血的比例明显高于正常对照组，早产儿、新生儿窒息、围生儿死亡明显高于正常对照组，两组比较差异有统计学意义(P<0.05)。结论 妊娠期肝内胆汁淤积症严重影响母婴安全，应加强孕期监护，必要时终止妊娠，减少并发症的发生，降低围生儿患病率及病死率。

    【关键词】妊娠期肝内胆汁淤积症；胎儿窘迫；早产；产后出血

    Intrahepatic cholestasis of pregnancy Perinatal Outcome

    【Abstract】Objective Intrahepatic cholestasis of pregnancy (ICP) on maternal and neonatal outcomes.Methods Retrospective analysis of 53 patients in our hospital intrahepatic cholestasis of pregnancy clinical data of pregnant women, while over the same period 60 cases of normal pregnant women were analyzed to compare maternal and perinatal outcome of children. ......