(辽宁中医药大学基础医学院, 辽宁沈阳，110032)

    【摘要】理论免疫学用数学的方法来研究和解决免疫学问题，以及对免疫学相关的数学方法进行理论研究的一门科学。随着高通量方法和基因组数据的出现，理论免疫学从受体交联和免疫原理、Jerne的相互作用网络和自我选择等经典建模方法开始向信息学、空间扩展模型、免疫遗传学和免疫信息学、进化免疫学、分子生物信息学和表遗传学、高通量研究方法和免疫组学等方面转变。

    【关键词】免疫学, 理论；数学模型；生物数学

    Advances of theoretical immunology

    JIN Yan

    (Basic medical college, Liaoning Universtity of Traditional Chinese Medicine, LIAONING Shenyang, 110032,)

    【Abstracts】Theoretical immunology is to develop mathematical methods that help to investigate the immunological problems, and to study the mathematical theory on immunology. With the advent of high-throughput methods and genomic data, immunological modeling of theoretical immunology shifted from receptor cross linking, Jerne interaction networks and self-non self selection, toward the informatics, spatially extended models, immunogenetics and immunoinformatics, evolutionary immunology, innate immunity and epigenetics, high-throughput research methods and Immunomics. Immunology, Theoretical; Mathematical Models; biomathematics

    理论免疫学[1](Theoretical Immunology)是指用数学的方法来研究和解决免疫学问题 ......