门冬胰岛素治疗妊娠糖尿病的临床效果观察(1)
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【摘要】目的：对比在妊娠糖尿病患者应用门冬胰岛素(诺和锐)与生物合成人胰岛素(诺和灵R)的疗效及安全性，总结其临床意义。方法：选取我院2007年4月至2008年4月70例妊娠糖尿病患者，随机分为观察组(门冬胰岛素治疗)和对照组(生物合成人胰岛素治疗)各35例。观察两组治疗前后空腹血糖值、餐后1 h血糖值、糖化血红蛋白、血糖达标时间、血糖达标时胰岛素日用量及低血糖发生率，记录相关数据，进行统计分析。结果：两组空腹血糖、餐后1 h血糖值、糖化血红蛋白对比无明显差异(P>0.05)；观察组的血糖达标时间、胰岛素日用量及低血糖发生率对比对照组均较低，差异显著(P<0.05)。结论：门冬胰岛素在强化降糖治疗妊娠糖尿病方面明显优于生物合成人胰岛素治疗，具有重要的临床意义，值得推广应用。
【关键字】妊娠糖尿病；门冬胰岛素；生物合成人胰岛素；安全性
Treatment of gestational diabetes, insulin aspart clinical observation
XIE Meixia
Zhengzhou Coal Industry Group, General Hospital, Zhengzhou 450000
【Abstract】 Objective: To compare in patients with gestational diabetes insulin aspart (aspart) and biosynthetic human insulin (Novolin R) efficacy and safety, summarize its clinical significance. Methods: in our hospital from April 2007 to April 2008 70 patients with gestational diabetes were randomly divided into two groups (insulin aspart) and the control group (biosynthetic human insulin treatment) in 35 patients each. Were observed before and after treatment fasting glucose, postprandial blood glucose levels 1 h, glycosylated hemoglobin, blood glucose time, daily dose of insulin when blood glucose and incidence of hypoglycemia, records relevant data for statistical analysis. Results: The fasting blood glucose, postprandial blood glucose levels 1 h, no significant difference in glycated hemoglobin compared (P> 0.05); observation group time blood glucose, insulin daily dose and the incidence of hypoglycemia was lower compared the control group, significant difference (P <0.05). Conclusion: The glucose insulin aspart treatment of gestational diabetes in strengthening the obviously superior to the biosynthesis of human insulin therapy, has important clinical significance, should be widely applied.
【Keywords】 gestational diabetes, insulin aspart safety of human insulin biosynthesis
妊娠糖尿病(GDM)指在妊娠期发生或发现的糖耐量异常或糖尿病，其发生率约为1% ~ 5%，由于GDM对母体和胎儿的影响较大，早期治疗意义巨大。 尽早采取胰岛素治疗将血糖控制在理想水平是减少并发症的主要措施。我院从2007年4月至2008年4月，对35例妊娠糖尿病患者应用门冬胰岛素(诺和锐)治疗，效果较好。现报告如下：
1资料和方法 ......
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