伊曲康唑联合达克宁栓治疗外阴阴道徦丝酵母菌病临床效果研究(1)
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【摘要】 目的：临床验证伊曲康唑联合达克宁栓治疗外阴阴道徦丝酵母菌病的临床效果、观察不良反应。方法：采用口服伊曲康唑、阴道放置达克宁栓，并且夫妻同时治疗。结果：①206例病例中200例治愈，总治愈率为97.1% ，复发率为1.94%。②服用斯皮仁诺后有12例出现不良反应，不良反应发生率为5.82%；使用达克宁栓治疗过程中19例出现轻微局部刺激，不良反应发生率为9.22%。结论：伊曲康唑联合达克宁栓治疗外阴阴道徦丝酵母菌病能起到互补作用，治愈率高，复发率低，副作用小、安全性好，是治疗外阴阴道徦丝酵母菌病的有效措施，值得在临床推广使用;夫妻同时治疗可提高治愈率、降低复发率。
【关键词】 伊曲康唑； 达克宁栓； 外阴阴道徦丝酵母菌病；治疗
Observation of the Clinical Effect of combined Itraconazole and Miconazole suppository on candidal vaginitis
Zhoushuping
( the people's hospital of baokang county,Hubei Province，Zip code :441600)
【Abstract】 Objective:To observe the efficacy and the adverse reactions of combined Itraconazole and Miconazole suppository in treating candidal vaginitis. Method:206 cases were treated with oral Itraconazole and vaginal administration of Miconazole suppository, and sexual partners were received therapy at the same time. Result: (1) 200 cases were cured and the total cure rate was 97.1%, and the recurrence rate was 1.94%.(2) In the course of taking Itraconazole ,12 patientshad adverse reactions, the incidence rate of adverse reaction was 5.82% ;in the course of treatment with Miconazole Suppository, 19 patients had adverse reactions, the incidence rate of adverse reaction was 9.22%. Conclusion: The cure rate of candidal vaginitis treated with systematic and local drug is high, the relapse rate is low, and the drugs are safety .Sexual partners were received therapy at the same time can improve the cure rate and reduce the recurrence.This measure is valued to be promoted the use in clinical.
【Key words】 Itraconazoleand; Miconazole suppository; Candidal vaginitis; Treated
外阴阴道徦丝酵母菌病是一种常见的外阴、阴道炎症，也称外阴阴道念珠菌病[1]。主要由白徦丝酵母菌感染所致。据统计，约3/4的女性在其一生中至少会发生一次外阴阴道念珠菌感染。初次发作时往往因为未得到规范、彻底治疗而引起反复发作。笔者采用斯皮仁诺口服联合达克宁栓阴道局部用药治疗外阴阴道徦丝酵母菌病临床效果显著、复发率低。
1 伊曲康唑与达克宁栓的药理作用及不良反应
1.1 伊曲康唑
1.1.1 药理作用及用途 伊曲康唑(itraconazole,ICZ)为三氮唑衍生物，是一种合成的广谱抗真菌药。对皮肤癣菌、酵母菌、曲霉菌属、组织胞浆菌属、巴西副球孢子菌、申克孢子丝菌、着色真菌、枝孢霉属、皮炎芽生以及各种其他的酵母和真菌感染等均有较强的抑制杀灭作用。主要用于主要应用于深部真菌所引起的感染。
1.1.2 不良反应 最常见于胃肠道系统，如：消化不良、恶心、呕吐、腹泻、腹痛和便秘。其次有头痛、可逆性的肝酶升高、肝炎、月经异常、眩晕和过敏反应(如：瘙痒、皮疹、荨麻疹和血管性水肿)、外周神经系统疾病、Stevens-Johnson综合征、脱发、低血钾、水肿、充血性心力衰和肺水肿。极罕见包括致命的急性肝脏衰竭在内的严重肝脏毒性病例。大多数不良反应可通过减少剂量而缓解。
1.2 达克宁栓
1.2.1 药理作用及用途 达克宁栓(硝酸咪康唑栓)咪康唑具有抗皮真菌、酵母菌活性 ......
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