丹红注射液联合脑心通对急性脑梗塞患者血浆炎性因子的影响及疗效观察(1)
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【摘要】 目的 观察丹红注射液联合脑心通治疗急性脑梗死的临床疗效及对患者血浆炎性因子变化的影响。方法 120例急性脑梗死患者随机分为两组：对照组60例，丹红注射液联合脑心通治疗组(治疗组)60例。治疗前和治疗两周后分别采用美国国立卫生研究所脑卒中评分(NIHSS)评定两组患者神经功能改变，观察临床疗效，同时采用放射免疫法测定两组患者血浆TNF-α、IL-6含量的变化。结果 治疗两周后两组神经功能缺损评分较治疗前明显改善，且治疗组优于对照组(P<0.01)，与对照组比较，治疗组总有效率、血浆TNF-α及IL- 6含量差异有统计学意义(P<0.05或P<0.01)。结论 丹红注射液联合脑心通胶囊能改善急性脑梗死患者的神经功能且有较好的疗效，其机制可能与降低患者血浆中TNF-α及IL-6有关。
【关键词】 急性脑梗死；丹红注射液；脑心通；肿瘤坏死因子-α；白细胞介素-6
Impact on Plasma Inflammatory Cytokines and Clinical Effect of Danhong Injection with Naoxintong Injection in Patients with Acute Cerebral Infarction
Hu Chunhua, Department of Traditional Chinese Medicine, Taojiang People's Hospital, Taojiang, Hunan, 413400
【Abstract】 Objective: To observe the clinical effect of Danhong injection with Naoxintong injection in the treatment of acute cerebral infarction and the impact on plasma inflammatory cytokines. Methods: 120 patients with acute cerebral infarction were randomly divided into two groups: 60 cases in the control group, while 60 cases in the treatment group of Danhong injection with Naoxintong injection (treatment group). Evaluated the changes of neurological function of patients in two groups according to National Institute of Health Stroke Scale (NIHSS) before and two weeks after the treatment, and observed the clinical effect and measured the changes of TNF-α and IL-6 content in the plasma by radioimmunoassay. Results: Neurological impairment scale of two groups was significantly improved two weeks after the treatment, while the effect of treatment group was significantly better than the one of control group (P<0.01). There were significant differences in the overall response rate, and contents of TNF-α and IL-6 in the plasma between the treatment group and control one (P<0.05, or P<0.01). Conclusion: There is good clinical effect of Danhong injection with Naoxintong injection in improving the neurological function of patients with acute cerebral infarction, and its mechanism may be related to the reduction of TNF-α and IL-6 in the plasma.
【Keywords】 Acute Cerebral Infarction; Danhong Injection; Naoxintong Injection; TNF-α; IL-6 ......
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