根除幽门螺杆菌治疗对反流性食管炎治疗的影响(附289例报告)
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【摘要】 目的：探讨根除幽门螺杆菌对反流性食管炎疗效影响。方法：选择2008年7月—2010年3月在我院门诊及住院部已确诊的289例RE患者，证实Hp感染，既往未行抗Hp治疗， HP阳性组随机分成两组：一组给予埃索美拉唑镁20mg Bid(阳性治疗组)；一组给予埃索美拉唑镁20mg Bid +根除HP治疗，对于Hp阴性组给予埃索美拉唑镁20mg Bid(阴性治疗组)，总的疗程为8周，8周后所有病人均复查胃镜及HP检测。结果 HP阴性组是206例， HP阳性组是83例(对照组30例，根除HP治疗组 53例)；根除治疗组中，其中8例未成功根除，HP根除率为96%，总的愈合率为80.27%，其中HP阳性对照组、HP阳性成功根除治疗组、HP阳性未成功根除治疗组、阴性对照组愈合率分别为76.7%、77.78%、和75%、81.55%，各组参数间差异均无统计学意义(P>0.05)。结论：我们的临床试验证明是否根除Hp治疗对反流性食管炎的愈合均不产生显著影响。
【关键词】 幽门螺杆菌；反流性食道炎
【Abstract】 To investigate the eradication of Helicobacter pylori on reflux esophagitis curative effect. Methods: 2008 July - 2010 March in our hospital outpatient and inpatient department has been diagnosed in 289 patients with RE, both positive confirmed Hp infection, previous without treatment against Hp, in HP positive group was randomly divided into two groups: one group of esomeprazole magnesium 20mg Bid ( positive treatment group); a group give esomeprazole magnesium 20mg Bid + HP eradication therapy, for Hp negative group given esomeprazole magnesium 20mg Bid ( positive treatment group), the total duration of treatment was 8 weeks, 8 weeks after all patients were reexamined with gastroscopy and HP detection. Results HP negative group is 206 cases, HP positive group was 83 cases ( 30 cases in the control group, HP eradication therapy group 53 cases ); eradication therapy group, including 8 cases of failed eradication, HP eradication rate was 9.6%, the total effective rate is 80.27%, where HP positive control group, HP positive success of eradication therapy group, HP positive failed eradication therapy group, negative control group healing rates were 76.7%, 77.78%, and 75%, 81.55% groups of parameters, there were no significant differences ( P > 0.05 ). Conclusion: our clinical trials prove whether Hp eradication therapy for reflux esophagitis healing has no remarkable influence.
【Key words】 Helicobacter pylori reflux esophagitis
幽门幽门螺杆菌(helicobacter pylori，Hp)在十二指肠球部溃疡、胃溃疡及慢性胃炎的发病中起着非常重要的作用，它与胃癌及胃黏膜相关淋巴瘤的发病也有较密切的关系。近年来反流性食道炎发病率逐渐增高，(reflux esophagitis，RE )， 但Hp与反流性食道炎的关系仍存在争议，国外有的资料显示Hp与RE的发生无关，但更多的资料显示Hp在RE的发生中起保护作用；那么胃食管反流病的患者是否需要根除幽门螺杆菌 ......
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