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    摘要：目的：PDL1广泛表达于肿瘤组织，因此，PDL1/PD1通路可能在肿瘤免疫逃逸中起到一定作用。本研究通过检测化疗药物作用前后PDL1在胶质瘤细胞的表达情况，为进一步研究其在胶质瘤靶向治疗中的作用提供实验依据。方法 利用流式细胞仪检测化疗药物作用前后PDL1在胶质瘤细胞株的表达。结果：胶质瘤细胞株高表达PDL1，化疗药物作用后PDL1的表达显著升高。结论 PDL1可以作为胶质瘤治疗的潜在靶点。

    关键词：PDL1;胶质瘤;化疗药物

    Abstract： Objective PDL1 is widely expressed in tumor tissues. Therefore， the PDL1/PD1 pathway may play a role in tumor immune escape. This study detected the expression of PDL1 in glioma cells before and after the action of chemotherapeutics， and provided experimental evidence for further research on its role in targeted therapy of glioma. Methods Flow cytometry was used to detect the expression of PDL1 in glioma cell lines before and after the action of chemotherapy drugs. Results The glioma cell line highly expressed PDL1 ......