ING4基因与肿瘤研究新进展(1)
[摘要] ING4基因是肿瘤抑制因子家族的新成员,近来研究发现,ING基因在正常组织中表达丰富,但在多种恶性肿瘤组织,如乳腺癌、胶质瘤、肺癌等中表达明显下调,ING4可通过增强p53基因的活性、恢复细胞间接触抑制、抑制肿瘤血管生成、抑制HIF的活性而抑制肿瘤的生长,还能诱导细胞凋亡,增加肿瘤细胞对放化疗的敏感性,本研究对ING4基因与肿瘤研究的新进展进行综述。[关键词] ING4基因;抑癌机制;肿瘤
[中图分类号] R730.5 [文献标识码] A [文章编号] 2095-0616(2011)13-42-03
Advancement of study between ING4 gene and tumor
PAN Xuan WANG Chaoxia
[Abstract] ING4 is considered to be a novel candidate tumor suppressor gene.Recently,it has been reported that ING4 was significantly downregulated in several m alignancies such as breast tumor ......
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