人脑星形细胞瘤STAT3的表达及意义(2)
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Burke等[6]研究发现在STAT3异常活化的卵巢癌和乳腺癌细胞中，使用选择性的JAK激酶抑制剂AG490和STAT3的显性负向突变体STAT3β能明显抑制卵巢癌和乳腺癌细胞的生长和诱导细胞凋亡， AG490通过阻断JAK-STAT3磷酸化途径使STAT3失活，抑制STAT3结合DNA调节靶基因转录，同时也能够使凋亡抑制基因Bcl-xL表达下调；而STAT3的失活对于正常组织细胞无明显影响。根据本实验结果结合相关文献分析STAT3 及P-STAT3蛋白与星形细胞瘤的发生发展关系非常密切，阻断STAT3信号途径可能成为星形细胞瘤治疗中一个新的治疗靶点。
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(收稿日期：2011-12-01)
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