HPLC法测定醋酸地塞米松片有关物质
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[摘要] 目的 建立HPLC法测定醋酸地塞米松片中有关物质。 方法 采用HPLC法，C18柱(250 mm×4.6 mm，5 μm)；流动相：乙腈-水(40∶60)；流速：1.0 mL/min；检测波长240 nm。 结果 有关物质的浓度在0.50～12.56 μg/mL范围内，与峰面积呈良好的线性关系(r=1)，醋酸地塞米松与其有关物质能有效分离，有关物质的最低检出限(S/N=3)为10 ng/mL。 结论 采用HPLC法测定醋酸地塞米松片的准确率高、专属性强，可用于该药有关物质的检查。
[关键词] 高效液相色谱法；醋酸地塞米松片；有关物质
[中图分类号] R927.2 [文献标识码] B [文章编号] 2095-0616(2012)05-99-02
HPLC determination of relative substances in dexamethasone acetate tablets
LI Qun
Department of Pharmacy, the First Hospital of Chifeng City, Chifeng 024000,China
[Abstract] Objective A method for the determination of relative substances in Dexamethasone Acetate Tablets was established. Methods CAPCEL PAK C18 column(250 mm×4.6 mm,5 μm);Acetonitrile–water(40:60)as the mobile phase;the flow rate was 1.0 mL/min,detecting wavelength was 240 nm. Results The linear range of relative substances was 0.50～12.56 μg/mL(r=1),Dexamethasone Acetate and relative substances could be effectively separated,the lowest detection limit of relative substance(S/N=3)was 10ng/mL. Conclusion The method was accurate,simple and specific ......
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