[摘要] 腰腿痛随着我国人口老龄化加剧逐渐增多，其主要原因为椎间盘机械或退变而导致的压迫神经，对其分子机制研究较多，本文通过对近年终板退变与间盘膨出及腰腿痛有关高迁移族转移蛋白的近期研究进展进行分析和比较，以期总结其相关性，分析其不足，为临床腰椎间盘突出症的诊治提供新的思路和方法。

    [关键词] 腰腿痛；高迁移族转移蛋白(HMGB1)；椎间盘退变

    [中图分类号] R681.5   [文献标识码] A   [文章编号] 2095-0616(2014)09-45-04

    HMGB1-The new targets of lumbar retrograde degeneration disease treatment

    ZHANG Zhehan  YANG Xuejun

    Department of Thoracic Lumbar Spine Surgery, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010010, China

    [Abstract] China's aging population has intensified ......