阿托伐他汀对脑梗死患者血脂水平及颈动脉内膜—中膜厚度的影响研究(1)
[摘要] 目的 脑梗死患者长期服用阿托伐他汀对血脂水平及颈动脉内中膜厚度的影响观察。 方法 将2012年1月～2014年3月我院收治的120例脑梗死患者按照随机数字表法分为两组，各60例，两组患者均给予脑梗死患者常规治疗及护理措施，研究组60例患者再加服阿托伐他汀片(20mg/d，每晚顿服，连用12个月)，对照组加服辛伐他汀片(20mg/d，每晚顿服，连用12个月)，对两组患者治疗前后的血脂相关指标及颈动脉内中膜厚度进行比较。 结果 两组患者经用药6个月后的血TC、TG水平均显著性降低(P<0.01)，但研究组降低幅度更为显著(P<0.05)；研究组用药后的血LDL水平较前明显降低(P<0.01)，血HDL水平较前升高(P<0.05)，对照组治疗前后的LDL、HDL水平无明显变化(P>0.05)。 结论 对脑梗死患者长期口服阿托伐他汀可有效改善其血脂水平，降低颈动脉粥样硬化发生风险，值得临床推广应用。
[关键词] 阿托伐他汀；脑梗死；血脂；动脉粥样硬化
, 百拇医药 [中图分类号] R743.3 [文献标识码] B [文章编号] 2095-0616(2015)11-80-03
[Abstract] Objective To observe the effect of atorvastatin on the blood lipid level and carotid artery intima-media thickness in patients with cerebral infarction who have taken atorvastatin for a long time. Methods 120 cases of the patients with cerebral infarction treated in our hospital from January 2012 to January 2014 were selected and randomly divided into 2 groups， 60 cases in each group. The patients in two groups were given routine treatment and nursing measures， but 60 cases of the patients in study group patients were also asked to take Atorvastatin tablets (20mg was taken every evening and it should last for 12 months) as part of the treatment while the patients in the control group were also asked to take Simvastatin tablets (20mg was taken every evening and it should last for 12 months). The Serum lipids and carotid artery intima-media thickness of the patients in two groups before and after treatment were compared. Results Six months after taking the medicine， the blood TC， TG levels of the patients in two groups were decreased significantly (P<0.01)， but the blood TC， TG levels of the patients in the study group demonstrated a significantly greater reduction (P<0.05). The blood LDL level of the patients in the study group after administration decreased significantly (P<0.01) and their blood HDL level increased than before (P<0.05). There were no significant changes in The LDL and HDL level of the patients in the control group before and after treatment (P>0.05). Conclusion That the patients with cerebral infarction take atorvastatin for a long time can effectively improve the blood lipid level and can reduce the risk of carotid atherosclerosis. This treatment is worthy of clinical application.
, 百拇医药
[Key words] Atorvastatin； Cerebral infarction； Blood lipid； Atherosclerosis
脑梗死是中老年人群常见的危急重症之一，具有起病急、恢复慢、致残率及致死率高的临床特征，同时绝大部分患者在急性脑梗死治疗后都会出现不同程度的后遗症情况[1]，患者神经、运动功能极可能遭受不可逆的破坏，对患者心理及生理健康造成严重影响。病理生理学研究证实，颈动脉粥样硬化斑块是导致脑梗死发生的主要危险因素，而血脂水平与动脉粥样硬化斑块的形成有直接联系，因此采取合理有效的治疗措施对脑梗死患者血脂水平进行控制及稳定颈动脉粥样硬化斑块显得十分重要。本研究在常规药物治疗及护理基础上给予60例脑梗死患者长期口服阿托伐他汀片，取得较满意效果，现将结果报道如下。, 百拇医药(韩金玲 杨春水 李建英等)
[关键词] 阿托伐他汀；脑梗死；血脂；动脉粥样硬化
, 百拇医药 [中图分类号] R743.3 [文献标识码] B [文章编号] 2095-0616(2015)11-80-03
[Abstract] Objective To observe the effect of atorvastatin on the blood lipid level and carotid artery intima-media thickness in patients with cerebral infarction who have taken atorvastatin for a long time. Methods 120 cases of the patients with cerebral infarction treated in our hospital from January 2012 to January 2014 were selected and randomly divided into 2 groups， 60 cases in each group. The patients in two groups were given routine treatment and nursing measures， but 60 cases of the patients in study group patients were also asked to take Atorvastatin tablets (20mg was taken every evening and it should last for 12 months) as part of the treatment while the patients in the control group were also asked to take Simvastatin tablets (20mg was taken every evening and it should last for 12 months). The Serum lipids and carotid artery intima-media thickness of the patients in two groups before and after treatment were compared. Results Six months after taking the medicine， the blood TC， TG levels of the patients in two groups were decreased significantly (P<0.01)， but the blood TC， TG levels of the patients in the study group demonstrated a significantly greater reduction (P<0.05). The blood LDL level of the patients in the study group after administration decreased significantly (P<0.01) and their blood HDL level increased than before (P<0.05). There were no significant changes in The LDL and HDL level of the patients in the control group before and after treatment (P>0.05). Conclusion That the patients with cerebral infarction take atorvastatin for a long time can effectively improve the blood lipid level and can reduce the risk of carotid atherosclerosis. This treatment is worthy of clinical application.
, 百拇医药
[Key words] Atorvastatin； Cerebral infarction； Blood lipid； Atherosclerosis
脑梗死是中老年人群常见的危急重症之一，具有起病急、恢复慢、致残率及致死率高的临床特征，同时绝大部分患者在急性脑梗死治疗后都会出现不同程度的后遗症情况[1]，患者神经、运动功能极可能遭受不可逆的破坏，对患者心理及生理健康造成严重影响。病理生理学研究证实，颈动脉粥样硬化斑块是导致脑梗死发生的主要危险因素，而血脂水平与动脉粥样硬化斑块的形成有直接联系，因此采取合理有效的治疗措施对脑梗死患者血脂水平进行控制及稳定颈动脉粥样硬化斑块显得十分重要。本研究在常规药物治疗及护理基础上给予60例脑梗死患者长期口服阿托伐他汀片，取得较满意效果，现将结果报道如下。, 百拇医药(韩金玲 杨春水 李建英等)