中西医联合治疗排卵性不孕症的临床疗效及对子宫内膜的影响分析(1)
[摘要] 目的 探讨中西医联合治疗排卵性不孕症的临床疗效及对子宫内膜改善状况的分析。方法 选择2013年7月～2014年12月来我院妇科门诊174例患者进行不孕不育治疗的为观察对象，随机分为3组。中药组41例，CC组46例，(中药+CC)组87例。观察并比较患者排卵情况，卵泡大小及子宫内膜发育情况，治疗后随访患者妊娠状况。结果 中药组及CC组妊娠率均显著低于(中药+CC)组，且流产率高于(中药+CC)组，差异具有统计学意义(P<0.05)。三组治疗后子宫内膜厚度比较，中药组及(中药+CC)组比较差异无统计学意义(P>0.05)，两组均显著高于CC组(P<0.05)，而CC组及(中药+CC)组的排卵率显著高于中药组(P<0.05)。结论 中药制剂联合克罗米芬治疗排卵性不孕症不仅可使患者排卵率得以提高，同时可改善子宫内膜对雌激素的敏感性，二者相辅相成，可在临床推广使用。
[关键词] 中药制剂；补肾活血；克罗米芬(CC)；排卵性不孕症；子宫内膜厚度；雌激素
[中图分类号] R271.19 [文献标识码] B [文章编号] 2095-0616(2016)09-63-03
, http://www.100md.com
[Abstract] Objective To explore and discuss the clinical curative effect and the improvement situation analysis on endometrium of integrated traditional and western medicine on treating ovulation infertility. Methods 174 patients with infertility treatment in gynecology clinic of my hospital from July 2013 to December 2014 were selected as the observation objects， who were randomly divided into three groups. There were 41 cases of the Chinese medicine group， 46 cases of the CC group， and 87 cases of the Chinese medicines combined with CC group. The ovulation situation， follicular size， and endometrial development in patients were observed and compared， the condition of pregnancy was followed after treatment. Results In the Chinese medicines group and CC group， the pregnancy rate was both significantly lower than that of the Chinese medicines combined with CC group， and the abortion rate was both dramatically higher than that of the Chinese medicines combined with CC group， the differences were statistically significant(P<0.05). After treatment， the endometrial thickness of the three groups were compared， there were no statistical differences between the Chinese medicines group and Chinese medicines combined with CC group(P>0.05)， the endometrial thickness of the two groups was significantly higher than that of the CC group(P<0.05)， the ovulation rate of the CC group and Chinese medicines combined with CC group was dramatically higher than that of the Chinese medicines group(P<0.05). Conclusion Chinese drugs pharmaceutics combined with clomiphene on treating ovulation infertility not only increased the ovulation rate， but also improved the sensitivity of endometrium on estrogen， the two were complementary， which could be promoted and applied in clinic.
, http://www.100md.com
[Key words] Chinese drugs pharmaceutics； Invigorating kidney and promoting blood circulation； Clomiphene(CC)； Ovulatory infertility； Endometrial thickness； Estrogen
排卵障碍是导致妇女不孕不育的一个重要因素，约占发病原因的27%～35%[1]。克罗米芬(CC)是有效促排卵药物，可将排卵率提高至75%～90%，但应用此药可使患者子宫内膜产生抗雌激素作用，降低子宫内膜容受性，患者的妊娠率仅为28%～38%[2]。中医中的补肾化瘀法常用来治疗不孕不育症，可使患者子宫内膜容受性改善[3]。本研究将中西医联合用于治疗排卵不孕症，探讨其临床效果，现报道如下。, http://www.100md.com(孙晓玲)
[关键词] 中药制剂；补肾活血；克罗米芬(CC)；排卵性不孕症；子宫内膜厚度；雌激素
[中图分类号] R271.19 [文献标识码] B [文章编号] 2095-0616(2016)09-63-03
, http://www.100md.com
[Abstract] Objective To explore and discuss the clinical curative effect and the improvement situation analysis on endometrium of integrated traditional and western medicine on treating ovulation infertility. Methods 174 patients with infertility treatment in gynecology clinic of my hospital from July 2013 to December 2014 were selected as the observation objects， who were randomly divided into three groups. There were 41 cases of the Chinese medicine group， 46 cases of the CC group， and 87 cases of the Chinese medicines combined with CC group. The ovulation situation， follicular size， and endometrial development in patients were observed and compared， the condition of pregnancy was followed after treatment. Results In the Chinese medicines group and CC group， the pregnancy rate was both significantly lower than that of the Chinese medicines combined with CC group， and the abortion rate was both dramatically higher than that of the Chinese medicines combined with CC group， the differences were statistically significant(P<0.05). After treatment， the endometrial thickness of the three groups were compared， there were no statistical differences between the Chinese medicines group and Chinese medicines combined with CC group(P>0.05)， the endometrial thickness of the two groups was significantly higher than that of the CC group(P<0.05)， the ovulation rate of the CC group and Chinese medicines combined with CC group was dramatically higher than that of the Chinese medicines group(P<0.05). Conclusion Chinese drugs pharmaceutics combined with clomiphene on treating ovulation infertility not only increased the ovulation rate， but also improved the sensitivity of endometrium on estrogen， the two were complementary， which could be promoted and applied in clinic.
, http://www.100md.com
[Key words] Chinese drugs pharmaceutics； Invigorating kidney and promoting blood circulation； Clomiphene(CC)； Ovulatory infertility； Endometrial thickness； Estrogen
排卵障碍是导致妇女不孕不育的一个重要因素，约占发病原因的27%～35%[1]。克罗米芬(CC)是有效促排卵药物，可将排卵率提高至75%～90%，但应用此药可使患者子宫内膜产生抗雌激素作用，降低子宫内膜容受性，患者的妊娠率仅为28%～38%[2]。中医中的补肾化瘀法常用来治疗不孕不育症，可使患者子宫内膜容受性改善[3]。本研究将中西医联合用于治疗排卵不孕症，探讨其临床效果，现报道如下。, http://www.100md.com(孙晓玲)