何惠 宋捷 邵佳琪 文雪梅 夏俊凯 梁文波

    [摘要]卵巢癌是女性常见且死亡率较高的恶性肿瘤之一。当前，标准的治疗方案以手术为主，辅以化疗的综合治疗。然而，卵巢癌晚期诊断率高达70%，大部分患者错失了最佳手术时机。因此，内科治疗成为提高患者预后的重要方法，其目标是延长患者的无进展生存期(PFS)、提高患者生活质量。其中化疗一直是主要的药物治疗手段，而且随着对卵巢癌发病机制研究的深入，越来越多药物显示出良好的抗癌活性并在临床治疗中取得一定的进展，为卵巢癌患者提供新的治疗手段，如靶向治疗和激素治疗。

    [关键词]卵巢癌;化疗;靶向治疗;激素治疗

    [中图分类号] R737.31 [文献标识码] A? [文章编号]2095-0616(2021)22-0053-04

    Research progress of drug therapy in the treatment of ovarian cancer

    HE? Hui1? SONG? Jie2? SHAO? Jiaqi1? WEN? Xuemei1? XIA? Junkai1? LIANG? Wenbo2

    1. Xinhua Clinical College， Dalian University， Liaoning， Dalian 116021， China;2. Medical College， Dalian University， Liaoning， Dalian 116622， China

    [Abstract] Ovarian cancer (OC) is one of the common malignant tumors in women with high mortality. At present， the surgery is the standard treatment method， supplemented by chemotherapy. However， the diagnosis rate of advanced OC is as high as 70%， and most patients miss the best operation opportunity. Therefore， medical treatment has become an important method to improve patients' prognosis， with the goal of prolonging patients' progression free survival (PFS) and improving patients' quality of life. Chemotherapy has always been the main drug treatment method ......