蒙婷 徐丹 李争 荆晶 李风森

    [摘要]赖氨酸琥珀酰化修饰是一种新型蛋白质翻译后修饰，在组蛋白中被发现，普遍存在于所有原核和真核生命体的细胞质和细胞核中，参与并调控几乎所有生命体的生物过程，与疾病密切相关。本文综述了赖氨酸琥珀酰化的特点、修饰位点的分布以及主要影响因素，归纳了 SIRT5调控琥珀酰化参与疾病发生发展的多种代谢途径，为进一步探索疾病的发病机制提供基础。

    [关键词]赖氨酸琥珀酰化;代谢;线粒体; SIRT5;疾病

    [中图分类号] R730.2? [文献标识码] A? [文章编号]2095-0616(2021)23-0039-05

    Advances in the study of the correlation between lysine succinylation modification and diseases

    MENG? Ting1? XU? Dan2? LI? Zheng2? JING? Jing2? LI? Fengsen1，2

    1.School of Traditional Chinese Medicine， Xinjiang Medical University， Xinjiang， Urumqi 830000， China;2.National Clinical Research Base of Traditional Chinese Medicine， the Fourth Affiliated Hospital of Xinjiang Medical University， Xinjiang， Urumqi 830000， China

    [Abstract] Lysine succinylation modification is a novel post-translational modification of protein identified in histones， which commonly exists in the cytoplasm and nucleus of all prokaryotic and eukaryotic living organisms， participates in and regulates biological processes of almost all living organisms， and is closely associated with diseases. This paper reviews the characteristics of lysine succinylation ......