王育璐 逄曙光

    [摘要]胆汁酸(BA)参与脂质和脂溶性维生素的吸收，在葡萄糖等能量代谢中起着重要作用。BA 的代谢失调和信号传导异常在多种疾病中起作用，包括血脂异常、非酒精性脂肪性肝病、糖尿病、肥胖、动脉粥样硬化、胆汁淤积、胆结石、肿瘤等。肠道法尼醇 X 受体(FXR)和 G 蛋白偶联胆汁酸受体5(TGR5)信号通路是重要的 BA 合成调节剂，它们是维持葡萄糖体内稳态的相关代谢调节剂，可将其转化为糖尿病治疗的新靶标。

    [关键词]胆汁酸;糖尿病;肠道法尼醇 X 受体; G 蛋白偶联胆汁酸受体5

    [中图分类号] R587.1;R-1? [文献标识码] A? [文章编号]2095-0616(2021)23-0070-04

    Progress? of the research? on diabetes mellitus and bile acid metabolism

    WANG? Yulu1? PANG? Shuguang2

    1. Teaching and Research Section of Internal Medicine， Weifang Medical University， Shandong， Weifang 261000， China;2. Department of Endocrinology， Ji'nan Central Hospital Affiliated to Shandong University， Shandong， Ji'nan 250000， China

    [Abstract] Bile acid (BA) is involved in the absorption of lipids and fat-soluble vitamins， which plays an important role in energy metabolism of glucose， etc. Bile acid metabolic disorders and abnormal signal conduction play a role in a variety of diseases， including dyslipidemia， nonalcoholic fatty liver disease， diabetes mellitus (DM)， obesity， atherosclerosis， cholestasis， gallstones， tumors， etc. The signal paths of intestinal farnesol X receptor (FXR) and G protein-coupled bile acid receptor 5(TGR5) are important regulators of bile acid synthesis. In addition ......