陈晓琴 成志国 陈广新 明照凯 钟彦 沈文哲 周志尊

    [摘要]脑梗死是大脑供血动脉的狭窄或闭塞，引起脑组织血液供应障碍从而导致脑组织坏死及软化。近年来，使用数值模拟技术分析脑梗死已逐渐成熟，可进行定量定性的计算。本研究查阅相关数值模拟研究内容，介绍相关参数指标，分析数值模拟技术应用于血管分叉病变及脑梗死研究，得出高低值壁面切应力的不同作用机制及高壁面压力导致斑块形成的可能机制，同时明确极低或较高壁面剪应力及高振荡剪切指数更易造成动脉粥样硬化斑块的形成，以及动脉血管改变(如狭窄或闭塞等)易发生不稳定的血流动力学变化，使脑梗死发生概率增大，明确了数值模拟技术在脑梗死发生中的重要作用。

    [关键词]脑梗死;数值模拟技术;动脉粥样硬化;壁面切应力;壁面压力

    [中图分类号]R739.4;R273? [文献标识码]A? [文章编号]2095-0616(2022)05-0057-04

    Research progress of the application of numerical simulation technology in cerebral infarction

    CHEN Xiaoqin? CHENG Zhiguo? CHEN Guangxin? MING Zhaokai? ZHONG Yan? SHEN Wenzhe? ZHOU Zhizun

    School of Medical Imaging，Mudanjiang Medical University，Heilongjiang，Mudanjiang 157011，China

    [Abstract] Cerebral infarction is the stenosis or occlusion of cerebral blood supply arteries，which leads to the blood supply disorder in brain tissues，thus resulting in brain tissue necrosis and softening. In recent years，the application of numerical simulation technology to analyze cerebral infarction has gradually grown mature，which can be used for quantitative and qualitative calculation. This paper refers to relevant numerical simulation researches ......