汪逸纯 张真真 万贵平

    [摘要] 白细胞介素-33(IL-33)作为白细胞介素-1细胞因子超家族的新成员，在各种疼痛反应过程中发挥调节作用。通过回顾炎症性疼痛、神经性疼痛、骨癌痛、手臂振动综合征、疼痛性膀胱综合征以及急性心肌梗死等疾病文献中的 IL-33含量，发现 IL-33在不同组织、系统中存在表达差异，且 IL-33可诱导生长刺激表达基因2 蛋白(ST2)受体广泛表达(尤其是辅助性 T2细胞和肥大细胞)，以核因子κB(NF-κB)依赖的方式产生促炎性物质，释放信号因子，促进下游通路中炎症反应的发生，进而参与 T 细胞介导的免疫应答，这为疼痛的治疗提供了新思路。

    [关键词] 白细胞介素-33;疼痛;促炎物质;免疫应答

    [中图分类号] R-1; R338? [文献标识码] A? [文章编号] 2095-0616(2022)06-0041-04

    A review of the relationship between IL-33 and pain and prospect

    WANG? Yichun? ZHANG? Zhenzhen? WAN? Guiping2

    1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine， Nanjing University of Chinese Medicine， Jiangsu， Nanjing 210000， China;2. Jiangsu Province Hospital on Integration of Chinese and Western Medicine， Jiangsu， Nanjing 210000， China

    [Abstract] Interleukin-33(IL-33)， a new member of the IL-1 superfamily of cytokines， plays a regulatory role in various pain responses. A literature review on IL-33 levels in various diseases such as inflammatory pain， neuropathic pain， bone cancer pain， hand-arm vibration syndrome， bladder pain syndrome， and acute myocardial infarction revealed that IL-33 is differentially expressed in different tissues and systems and IL-33 can induce growth stimulation expressed gene 2 protein (ST2) receptor (especially in T-helper 2 cells and mast cells) expresses extensively ......