陈盼盼 孙想妹 方敏 潘海滔

    [摘要]子痫前期是一个与母体和胎儿健康有密切联系的孕期并发症，临床表现涉及多个系统，最常见的临床症状包括新发的高血压和蛋白尿。如果患者的临床症状不能得到有效控制，该疾病进展、恶化后多表现为多器官功能障碍。在过去的十年里，人们对于子痫前期的病理生理学有了新的理解，胎盘释放的血管生成因子和抗血管生成因子在该病的预测和治疗方面起到了非常重要的作用。本文讨论了血管生成标志物在子痫前期发病中的作用，并介绍该领域预测和治疗子痫前期的新策略。

    [关键词]子痫前期;血管生成标志物;血管内皮细胞生长因子;胎盘生长因子

    [中图分类号] R-1; R714.24? [文献标识码] A? [文章编号]2095-0616(2022)07-0040-04

    The role of angiogenic markers in predicting pre-eclampsia CHEN? Panpan1? SUN? Xiangmei1? ?FANG? Min2? PAN? Haitao2

    1. School of Medicine， Shaoxing University， Zhejiang， Shaoxing 312000， China;2. Shaoxing Maternity and Child Health Care Hospital， Zhejiang， Shaoxing 312000， China

    [Abstract] Pre-eclampsia is a pregnancy complication closely associated with maternal and fetal health， with clinical manifestations involving multiple systems， and the most common clinical symptoms including new-onset hypertension and proteinuria. If the patient’s clinical symptoms are not effectively controlled， the disease progresses and worsens mostly in the form of multi-organ dysfunction. Over the last decade， a new understanding of the pathophysiology of pre-eclampsia has emerged ......