【摘 要】 目的：探讨抗环瓜氨酸肽(抗CCP)抗体与类风湿关节炎患者合并肺间质性病变的相关性。方法：选取75例RA患者，所有患者均行胸部HRCT检查，对肺间质性病变进行半定量评分；采用酶联免疫吸附法测定抗CCP抗体(阴性参考区间为0～5 RU·mL-1)，按照其定性结果进行分组。观察抗CCP抗体阴性组及阳性组间肺间质性病变的评分有无差异。结果：抗CCP抗体阳性组与阴性组比较，各影像学表现出现的频次差异无统计学意义(P > 0.05)；但抗CCP抗体与弥漫性肺间质性病变间有相关趋势(P = 0.061)。抗CCP抗体阳性组肺间质性病变的半定量评分高于阴性组(平均秩序为40.43和28.30，P < 0.05)。结论：抗CCP抗体与类风湿关节炎肺间质性病变相关，抗体阳性者病变较阴性者重。

    【关键词】 关节炎，类风湿；抗CCP抗体；肺间质性病变；HRCT；半定量评分

    doi：10.3969/j.issn.2095-4174.2015.08.003

    【ABSTRACT】Objective：To investigate the correlation between anti CCP antibody and rheumatoid arthritis with interstitial lung disease.Methods：75 patients with rheumatoid arthritis were underwent chest HRCT to get semiquantitative scores.Enzyme-linked immunosorbent assay(ELISA)was used to determine the CCP antibody (The negative reference interval is 0～5 RU·mL-1) and the patients were grouped according to the results.The differences of scores of interstitial lung disease between the negative and positive groups were observed.Results：There was no significant difference in the frequency of CCP(P > 0.05) ......