筋骨痛宁胶囊联合氨基葡萄糖治疗膝骨关节炎临床观察(1)
【摘 要】目的：观察筋骨痛宁胶囊联合氨基葡萄糖治疗膝骨关节炎的临床疗效。方法：将90例膝骨关节炎患者随机分为治疗组和对照组，每组45例。对照组给予氨基葡萄糖口服治疗，治疗组在对照组治疗基础上加服筋骨痛宁胶囊，2组1个疗程均为3个月。观察2组临床疗效、VAS评分、Lysholm评分改善情况。结果：治疗组显效15例，有效23例，无效7例，总有效率为84.44%；对照组显效9例，有效21例，无效15例，总有效率为66.67%。2组比较，差异有统计学意义(P < 0.05)。治疗后，治疗组VAS评分和Lysholm评分较治疗前有明显改善，差异有统计学意义(P < 0.01)；与对照组比较，差异有统计学意义(P < 0.01或P < 0.05)。结论：筋骨痛宁胶囊联合氨基葡萄糖治疗膝骨关节炎疗效良好，值得应用推广。
【关键词】 骨关节炎，膝；氨基葡萄糖；筋骨痛宁胶囊
【ABSTRACT】Objective：To observe the clinical curative effect of Jingu Tongning Jiaonang (筋骨痛宁胶囊)combining glucosamine in the treatment of knee osteoarthritis.Methods：Ninety cases of knee osteoarthritis were randomly divided into a treatment group and a control group，45 cases in each.The control group was orally given glucosamine，while the treatment group was treated with Jingu Tongning Jiaonang combining glucosamine，both group treated for 3 months as a course.Their clinical efficacy，VAS score and Lysholm score were observed.Results：In the treatment group，15 cases were markedly effective，23 cases were effective，and 7 cases were ineffective，the total effective rate being 84.44%；while in the control group，9 cases were markedly effective，21 cases were effective，and 15 cases were ineffective，the total effective rate being 66.67%.The difference between the two groups was statistically significant (P < 0.05).After treatment，the VAS score and the Lysholm score of the treatment group were significantly improved compared with those before treatment，and the difference was statistically significant (P < 0.01)，while the difference was statistically significant (P < 0.01 or P < 0.05) compared with the control group.Conclusion：Jingu Tongning Jiaonang combining glucosamine has a good curative effect in the treatment of knee osteoarthritis，worthy of application and promotion.
【Keywords】 osteoarthritis，knee；glucosamine；Jingu Tongning Jiaonang(筋骨痛宁胶囊)
膝骨关节炎(knee osteoarthritis，KOA)是一种慢性、进行性骨关节病，多发于中老年人，主要临床表现为膝关节疼痛及功能障碍，严重者关节肿大变形等，对患者的生活、工作造成严重的影响。随着我国人口老龄化加剧，KOA的发病率也呈现上升的趋势[1]。现代医学治疗主要采用非甾体抗炎药，如布洛芬等缓解疼痛症状，氨基葡萄糖等药物修复关节软骨以延缓病变进展；但是长期使用非甾体抗炎药存在胃肠道刺激及肝肾毒性等不良反应。中医学主要是在辨证论治基础上，采用补肝肾壮筋骨、行气止痛、活血化瘀等药物治疗KOA。本院采用院内制剂筋骨痛宁胶囊联合氨基葡萄糖治疗KOA患者45例，现总结报告如下。
1 临床资料
1.1 一般资料 选取2013年1月至2014年1月在濮阳市中医院门诊就诊的KOA患者90例，按照随机数字表法分为治疗组和对照组，每组45例。治疗组男25例，女20例；年龄49～62岁，平均(55.22±3.95)岁；病程6～81个月，平均(47.20±22.79)个月；单侧20例，双侧25例。对照组男21例，女24例；年龄49～62岁，平均(54.29±3.56)岁；病程5～82个月，平均(46.62±19.56)个月；单侧18例，双侧27例。2组患者在性别、年龄、病程和患病部位等方面比较，差异无统计学意义(P > 0.05)，具有可比性。
1.2 诊断标准
1.2.1 西医诊断标准 按照2007年《骨关节炎诊治指南》[2]中KOA诊断标准。, 百拇医药(刘怀省 韩文朝)
【关键词】 骨关节炎，膝；氨基葡萄糖；筋骨痛宁胶囊
【ABSTRACT】Objective：To observe the clinical curative effect of Jingu Tongning Jiaonang (筋骨痛宁胶囊)combining glucosamine in the treatment of knee osteoarthritis.Methods：Ninety cases of knee osteoarthritis were randomly divided into a treatment group and a control group，45 cases in each.The control group was orally given glucosamine，while the treatment group was treated with Jingu Tongning Jiaonang combining glucosamine，both group treated for 3 months as a course.Their clinical efficacy，VAS score and Lysholm score were observed.Results：In the treatment group，15 cases were markedly effective，23 cases were effective，and 7 cases were ineffective，the total effective rate being 84.44%；while in the control group，9 cases were markedly effective，21 cases were effective，and 15 cases were ineffective，the total effective rate being 66.67%.The difference between the two groups was statistically significant (P < 0.05).After treatment，the VAS score and the Lysholm score of the treatment group were significantly improved compared with those before treatment，and the difference was statistically significant (P < 0.01)，while the difference was statistically significant (P < 0.01 or P < 0.05) compared with the control group.Conclusion：Jingu Tongning Jiaonang combining glucosamine has a good curative effect in the treatment of knee osteoarthritis，worthy of application and promotion.
【Keywords】 osteoarthritis，knee；glucosamine；Jingu Tongning Jiaonang(筋骨痛宁胶囊)
膝骨关节炎(knee osteoarthritis，KOA)是一种慢性、进行性骨关节病，多发于中老年人，主要临床表现为膝关节疼痛及功能障碍，严重者关节肿大变形等，对患者的生活、工作造成严重的影响。随着我国人口老龄化加剧，KOA的发病率也呈现上升的趋势[1]。现代医学治疗主要采用非甾体抗炎药，如布洛芬等缓解疼痛症状，氨基葡萄糖等药物修复关节软骨以延缓病变进展；但是长期使用非甾体抗炎药存在胃肠道刺激及肝肾毒性等不良反应。中医学主要是在辨证论治基础上，采用补肝肾壮筋骨、行气止痛、活血化瘀等药物治疗KOA。本院采用院内制剂筋骨痛宁胶囊联合氨基葡萄糖治疗KOA患者45例，现总结报告如下。
1 临床资料
1.1 一般资料 选取2013年1月至2014年1月在濮阳市中医院门诊就诊的KOA患者90例，按照随机数字表法分为治疗组和对照组，每组45例。治疗组男25例，女20例；年龄49～62岁，平均(55.22±3.95)岁；病程6～81个月，平均(47.20±22.79)个月；单侧20例，双侧25例。对照组男21例，女24例；年龄49～62岁，平均(54.29±3.56)岁；病程5～82个月，平均(46.62±19.56)个月；单侧18例，双侧27例。2组患者在性别、年龄、病程和患病部位等方面比较，差异无统计学意义(P > 0.05)，具有可比性。
1.2 诊断标准
1.2.1 西医诊断标准 按照2007年《骨关节炎诊治指南》[2]中KOA诊断标准。, 百拇医药(刘怀省 韩文朝)