and IgG and IgA increased(P < 0.05)before and after the treatment in the group without elevation of immunoglobulin.④The results of the correlation analysis showed that IgG was positively related to ESR，RF，VAS and DAS28 in peripheral blood of RA patients，and negatively correlated with BTLA and Treg(P < 0.05)；IgA was positively correlated with ESR，CRP，RF，and Anti CCP antibody(P < 0.05 or P < 0.01)；and IgM was positively correlated ESR ......