塞来昔布对骨关节炎大鼠软骨组织AQP1和AQP3表达影响的研究(2)
(P < 0.01)，and AQP3 mRNA and protein expressions were lower(P < 0.01).Conclusion：Celecoxib can reduce the distribution and expression of AQP3 and the permeability of cartilage tissue，which may be one of the potential mechanisms of treating osteoarthritis.【Keywords】 osteoarthritis;celecoxib;aquaporin 1;aquaporin 3;rats
骨关节炎(osteoarthritis，OA)是常见的退行性疾病，发病率随人口老龄化而逐年增高，其病理变化以关节软骨变性和继发性骨质增生为主[1]，具体发病机制仍未明确。软骨细胞是软骨中唯一的细胞成分 ......
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