李丹 石红 孔祥红 张景利

    【摘 要】目的：探究类风湿关节炎患者外周血调节性T细胞(Treg细胞)分泌白细胞介素-35(IL-35)水平与其发病的相关性。方法：选取类风湿关节炎患者70例作为观察组，健康体检者70例为对照组。采集2组外周血，检测Treg细胞数量、Foxp3荧光强度、IL-35水平。同时将观察组患者按照28个关节疾病活动度评分(DAS28评分)分为不同的组，对各组Treg细胞、Foxp3荧光强度、IL-35水平进行检测。结果：观察组患者外周血中Treg细胞高于对照组，IL-35水平低于对照组，差异有统计学意义(P 0.05)。各DAS28评分组RA患者的Treg细胞、IL-35水平比较，差异有统计学意义(P 0.05)。结论：类风湿关节炎患者外周血中Treg细胞数量明显上升，IL-35水平显著下降。由于Treg细胞功能缺陷，降低了负调控能力。

    【關键词】 类风湿关节炎;外周血调节性T细胞;白细胞介素-35;相关性

    The Correlation Between the Level of IL-35 Secreted by Treg Cells in Peripheral Blood and the Pathogenesis of Rheumatoid Arthritis

    LI Dan，SHI Hong，KONG Xiang-hong，ZHANG Jing-li

    【ABSTRACT】Objective：To investigate the correlation between the level of IL-35 secreted by Treg cells in peripheral blood and the pathogenesis of rheumatoid arthritis(RA).Methods：Seventy RA patients were selected as an observation group and 70 healthy physical examinees were selected as a control group.The peripheral blood of both groups was collected.The number of Treg cells ......