化痰法治疗肝癌的研究

    谢晓蔚，杨金坤*

    (上海中医药大学附属龙华医院肿瘤一科，上海 200032)

    摘要：现代病机研究从宏观视角和微观角度探索了“痰”在原发性肝癌发生、发展及转移中作用，明确了“痰”是肝癌产生的物质基础，发展了肝癌的痰证学说。临床实际中，化痰法治疗肝癌在控制瘤体、延长生存期、改善症状、改善生活质量等方面表现出较好的疗效，尤其是名老中医的治则治法值得进一步开发研究。实验研究方面也从分子水平上探索了单味化痰类中药以及中药复方治疗肝癌的机制与抑制肝癌细胞生长、促进肝癌细胞凋亡、抑制肿瘤血管生成、干扰细胞周期、抑制肿瘤细胞DNA 合成等有关。

    关键词：原发性肝癌； 肝肿瘤 ；化痰法

    DOI:10.13463/j.cnki.cczyy.2015.06.021

    中图分类号：R273文献标志码：A

    文章编号：2095-6258(2015)06-1153-04

    基金项目：国家中医药管理局中医临床指南应用评价项目( 肝癌)[ZYYBZ-2013(PJ26)]。

    作者简介：谢晓蔚(1991-)，女，硕士研究生，主要从事中西医结合治疗消化系恶性肿瘤的研究。

    收稿日期:(2015-05-19)

    *通信作者：杨金坤，电话-13621935353，电子信箱-jinkunyang@126.com

    Advances in phlegm treatment of liver cancer

    XIE Xiaowei, YANG Jinkun*

    (Tumor Department Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,

    Shanghai 200032, China)

    Abstract：Phlegm resistance is one of the important pathogenesis of malignant tumors, liver cancer as well. Modern pathogenesis research from the macro perspective and micro perspective to explore the “phlegm” occurred in primary liver cancer development and metastasis in effect, a clear “sputum” is the material basis of liver cancer produced phlegm syndrome theory developed liver cancer. Clinical practice, phlegm Treatment of liver cancer in control tumor and prolong survival and improve symptoms, improve quality of life demonstrated a good effect, especially worthy of old TCM therapeutic principle for further research and development. Experimental research also explored the molecular level of a single flavor phlegm medicine and traditional Chinese medicine to treat liver cancer mechanisms and inhibition of liver cancer cell growth and promote apoptosis of liver cancer cells and inhibit tumor angiogenesis, interfere with cell cycle, inhibition of tumor cell DNA synthesis related. ......