【摘要】目的 探讨IgG、Integrinβ6(整合素β6)、P16在人脑胶质瘤中的表达及其与患者预后的关系。方法 采用免疫组化SP二步法检测IgG、Integrinβ6、P16在55例胶质瘤和20例正常脑组织中的表达，原位杂交检测IgG mRNA在胶质瘤组织中的表达。结果 IgG、Integrinβ6、P16的表达阳性率在正常脑组织与胶质瘤组均有显著性差异(P均<0.05)，胶质瘤中IgG 与Integrinβ6的表达呈正相关(P<0.05)，IgG与P16表达呈负相关(P<0.05)。结论 胶质瘤中P16低表达，IgG、Integrinβ6高表达可能在胶质瘤的发生发展中起一定作用。

    【关键词】胶质瘤；IgG；Integrinβ6；P16；免疫组化；原位杂交

    【中图分类号】R739.41 【文献标识码】A 【文章编号】ISSN.2095-6681.2017.02..02

    【Abstract】Objective To investigate the expression of IgG、Integrinβ6 and P16 in human glioma.Methods The expression of IgG、Integrinβ6 and P16 in tissue samples from 55 cases with glioma and 20 cases with normal brain tissue was detected by “SP two steps” of immunohistochemistry.Results Integrinβ6 and P16 between glioma tissue and normal brain tissue(P<0.05).There was a positive correlation between IgG and Integrinβ6 expression (P<0.05) ......