阿莫西林与兰索拉唑治疗幽门螺杆菌相关性十二指肠溃疡的临床分析(1)
【摘要】目的 分析兰索拉唑联合阿莫西林治疗幽门螺杆菌相关性十二指肠溃疡的效果，探讨联合用药的价值。方法 选取我院收治的幽门螺杆菌相关性十二指肠溃疡患者70例作为研究对象，35例为对照组服用阿莫西林联合奥美拉唑治疗，35例为观察组服用阿莫西林联合兰索拉唑；对比两组患者疾病恢复和预后改善情况，以治疗总有效率和不良反应发生率为观察指标评价效果。结果 观察组治疗总有效率明显高于对照组，疾病恢复和预后改善总体效果明显优于对照组，统计学比较均有差异(P<0.05)；就不良反應发生率进行比较(P>0.05)，治疗安全性均较高。结论 兰索拉唑联合阿莫西林治疗幽门螺杆菌相关性十二指肠溃疡效果更为理想，能够有效促进患者病情的快速恢复黄和预后的改善，提高治疗总有效率且安全性高，临床应用推广价值高。
【关键词】兰索拉唑；阿莫西林；HP；十二指肠溃疡；效果观察
【中图分类号】R574.1 【文献标识码】A 【文章编号】ISSN.2095-6681.2018.02..02
【Abstract】Objective To analyze the effect of lansoprazole combined with amoxicillin in the treatment of Helicobacter pylori-associated duodenal ulcer and explore the value of combination therapy.Methods Seventy patients with Helicobacter pylori-associated duodenal ulcer admitted to our hospital were enrolled in this study.35 patients were treated with amoxicillin combined with omeprazole in the control group and 35 patients in the observation group were given amoxicillin combined Lansoprazole； compared the two groups of patients with disease recovery and prognosis to improve the total effective rate of treatment and the incidence of adverse reactions as indicators to evaluate the effect.Results The total effective rate in the observation group was significantly higher than that in the control group， and the overall effect of disease recovery and prognosis improvement was better than that of the control group (P<0.05). The incidence of adverse reactions was compared with P> 0.05， and the safety of treatment Sex is higher. Conclusion Lansoprazole combined with amoxicillin in the treatment of Helicobacter pylori associated duodenal ulcer effect is more ideal， can effectively promote the rapid recovery of the patient's condition
yellow and prognosis，improve the total effective rate of treatment and high safety， Clinical application of high value.
【Key words】lansoprazole； amoxicillin；HP；duodenal ulcer；effect observation
1 资料与方法
1.1 一般资料
本研究特地选取我院于2016年1月～2017年6月期间收治的幽门螺杆菌相关性十二指肠溃疡患者70例，其中男性患者40例，女性患者30例，平均年龄(45.62±8.56)岁；按照入院序号随机分为对照组和观察组，比较两组患者的基本资料，P>0.05无统计学意义。
1.2 临床病例选择标准
(1)两组患者均经检查确诊为幽门螺杆菌相关性十二指肠溃疡疾病；(2)两组患者均未有其他严重的并发症，均未有其他严重的器官病变；(3)两组患者均未有相关药物过敏史；(4)两组患者均在了解本研究相关内容后自愿参与。
1.3 治疗方法
两组患者入院后先行基础的检查确诊病情；两组患者均服用阿莫西林，每日三时服用，最大剂量不得超过0.2 g；对照组给予奥美拉唑，仅晨起服用1次，每日20 mg；观察组则服用兰索拉唑治疗，同样仅晨起服用1次，每日剂量为
30 mg，两组患者均给予为期一个月的治疗。
1.4 观察项目和指标
比较两种治疗方案的效果，分设为显效、有效和无效三个级别；显效：经实验室检查幽门螺杆菌全部阴转，胃镜检查溃疡部位明显愈合，患者的临床症状得到缓解；有效：患者的各项临床症状改善，溃疡部位逐渐愈合，溃疡面积明显缩小，出血情况有效缓解；无效：患者的病情无明显好转迹象甚至出现恶化；比较两组患者治疗后不良反应的发生情况，比较两组患者疾病恢复和预后改善的情况，以临床症状痊愈时间、幽门螺杆菌清除率及疾病复发率作为观察指标，跟踪随访半年后观察检查患者的疾病复发情况。, http://www.100md.com(刘文英)
【关键词】兰索拉唑；阿莫西林；HP；十二指肠溃疡；效果观察
【中图分类号】R574.1 【文献标识码】A 【文章编号】ISSN.2095-6681.2018.02..02
【Abstract】Objective To analyze the effect of lansoprazole combined with amoxicillin in the treatment of Helicobacter pylori-associated duodenal ulcer and explore the value of combination therapy.Methods Seventy patients with Helicobacter pylori-associated duodenal ulcer admitted to our hospital were enrolled in this study.35 patients were treated with amoxicillin combined with omeprazole in the control group and 35 patients in the observation group were given amoxicillin combined Lansoprazole； compared the two groups of patients with disease recovery and prognosis to improve the total effective rate of treatment and the incidence of adverse reactions as indicators to evaluate the effect.Results The total effective rate in the observation group was significantly higher than that in the control group， and the overall effect of disease recovery and prognosis improvement was better than that of the control group (P<0.05). The incidence of adverse reactions was compared with P> 0.05， and the safety of treatment Sex is higher. Conclusion Lansoprazole combined with amoxicillin in the treatment of Helicobacter pylori associated duodenal ulcer effect is more ideal， can effectively promote the rapid recovery of the patient's condition
yellow and prognosis，improve the total effective rate of treatment and high safety， Clinical application of high value.
【Key words】lansoprazole； amoxicillin；HP；duodenal ulcer；effect observation
1 资料与方法
1.1 一般资料
本研究特地选取我院于2016年1月～2017年6月期间收治的幽门螺杆菌相关性十二指肠溃疡患者70例，其中男性患者40例，女性患者30例，平均年龄(45.62±8.56)岁；按照入院序号随机分为对照组和观察组，比较两组患者的基本资料，P>0.05无统计学意义。
1.2 临床病例选择标准
(1)两组患者均经检查确诊为幽门螺杆菌相关性十二指肠溃疡疾病；(2)两组患者均未有其他严重的并发症，均未有其他严重的器官病变；(3)两组患者均未有相关药物过敏史；(4)两组患者均在了解本研究相关内容后自愿参与。
1.3 治疗方法
两组患者入院后先行基础的检查确诊病情；两组患者均服用阿莫西林，每日三时服用，最大剂量不得超过0.2 g；对照组给予奥美拉唑，仅晨起服用1次，每日20 mg；观察组则服用兰索拉唑治疗，同样仅晨起服用1次，每日剂量为
30 mg，两组患者均给予为期一个月的治疗。
1.4 观察项目和指标
比较两种治疗方案的效果，分设为显效、有效和无效三个级别；显效：经实验室检查幽门螺杆菌全部阴转，胃镜检查溃疡部位明显愈合，患者的临床症状得到缓解；有效：患者的各项临床症状改善，溃疡部位逐渐愈合，溃疡面积明显缩小，出血情况有效缓解；无效：患者的病情无明显好转迹象甚至出现恶化；比较两组患者治疗后不良反应的发生情况，比较两组患者疾病恢复和预后改善的情况，以临床症状痊愈时间、幽门螺杆菌清除率及疾病复发率作为观察指标，跟踪随访半年后观察检查患者的疾病复发情况。, http://www.100md.com(刘文英)