早期小剂量地塞米松对急性胰腺炎治疗效果的影响研究(1)
【摘要】目的 探討早期对急性胰腺炎治疗时小剂量使用地塞米松对治疗效果的影响。方法 选取2017年3月～2018年3月在我院就诊的210例急性胰腺炎患者作为研究对象，随机将其分为治疗一组、治疗二组和对照组三组。对照组患者给予常规方法治疗；治疗一组在对照组治疗的基础上，从初入院开始立即给予小剂量地塞米松静脉注射；治疗二组在对照组治疗的基础上，当病情加重时给予小剂量地塞米松静脉注射。观察比较三组患者治疗后腹痛缓解时间、血清(尿)淀粉酶恢复时间、胰周渗出吸收好转及平均住院天数等。结果 治疗后腹痛缓解时间：治疗一组为(3.2±1.3)d，治疗二组为(30.8±1.9)d，对照组为(4.1±2.7)d；胰周渗出吸收好转的时间：治疗一组为(7.1±2.5)d，治疗二组为(8.2±3.7)d，对照组为(10.3±3.2)d；治疗后血清(尿)淀粉酶恢复时间：治疗一组为(5.2±1.8)d，治疗一二组(6.2±1.5)d，对照组为(4.2±2.7)d；平均住院天数治疗一组为(9.2±3.4)d，治疗二组为(10.8±3.9)d，对照组为(13.6±4.9)d，表明治疗一组的治疗效果显著优于其他两组，差异具有统计学上的意义(P<0.05)。此外，研究表明：治疗一组共治愈44例，显效13例，有效11例，无效2例，总有效数68例，有效率约为为97.1%；治疗二组治愈25例，显效19例，有效16例，无效10例，总有效数为60例，总有效率为85.6%；对照组治愈28例，显效18例，有效13例，无效11例，总有效数59例，总有效率84.2%，由此可知治疗一组的疗效优于对照组，差异具有统计学上的意义(P<0.05)，而治疗二组与对照组的差异比较无统计学上的意义(P>0.05)。结论 早期对急性胰腺炎治疗时小剂量使用地塞米松可以降低急性胰腺炎患者的炎症，提高治疗效果。
【关键词】早期；地塞米松；急性胰腺炎；治疗；影响
【中图分类号】R576 【文献标识码】A 【文章编号】ISSN.2095-6681.2018.24..02
Study on the effect of early low dose dexamethasone on
the treatment of acute pancreatitis
DU Fan-rong
(Department of pharmacy，Wulanchabu city central hospital，Neimenggu Wulanchabu 012000，China)
【Abstract】Objective To investigate the effect of low dose dexamethasone on treatment of acute pancreatitis in early stage.Methods 210 patients with acute pancreatitis who were treated in our hospital in March 2017～2018 March were randomly divided into two groups：treatment group，treatment group and control Group Three.In the control group，patients were treated with conventional methods，and the treatment group was treated in control group， and the small doses of dexamethasone were administered immediately from the initial admission，and the second group was treated in the control group，and the small dosage of dexamethasone was injected when the condition was aggravated. The relief time of abdominal pain， the recovery time of serum (urine) amylase，the improvement of exudation and the average length of hospitalization were compared in three groups.Results Treatment of postoperative abdominal pain relief Time：Treatment of a group of (3.2±1.3) d，the therapy group was (30.8±1.9) d，the control group was (4.1±2.7) d，the time of the peripheral exudation of the pancreas was improved：the treatment group (7.1±2.5) d，the treatment group (8.2±3.7) d，the control group (10.3±3.2) d，the serum after treatment.Urine amylase recovery time：Treatment of a group of (5.2±1.8)d，treatment of Group One or two (6.2±1.5) d，control Group (4.2±2.7) d，average length of stay in one group (9.2±3.4) d，treatment of two groups (10.8±3.9) D，control Group (13.6±4.9) d，showed that treatment of a group of patients significantly superior to other In both groups，the difference was statistically significant (p<0.05). In addition，the study showed that：treatment of a group of 44 cases of total cure，the results were 13 cases， effective 11 cases， invalid 2 cases，total effective number 68 cases，the efficiency was about 97.1%，treatment of the two groups were 25 cases，the effect was 19，effective 16 cases，invalid 10 cases，total effective number was 60，the total effective rate was 85.6%. Control group Cured 28 cases， 18 cases， effective 13 cases， invalid 11 cases，total effective number 59 cases，total effective rate 84.2%，it is better to treat a group of curative effect than control group，The difference was statistically significant (P<0.05)，and there was no statistically significant difference between the two treatment groups and the control group (P>0.05).Conclusion Low dose dexamethasone in early treatment of acute pancreatitis can reduce inflammation and improve therapeutic effect in patients with acute pancreatitis., http://www.100md.com(杜凡荣)
【关键词】早期；地塞米松；急性胰腺炎；治疗；影响
【中图分类号】R576 【文献标识码】A 【文章编号】ISSN.2095-6681.2018.24..02
Study on the effect of early low dose dexamethasone on
the treatment of acute pancreatitis
DU Fan-rong
(Department of pharmacy，Wulanchabu city central hospital，Neimenggu Wulanchabu 012000，China)
【Abstract】Objective To investigate the effect of low dose dexamethasone on treatment of acute pancreatitis in early stage.Methods 210 patients with acute pancreatitis who were treated in our hospital in March 2017～2018 March were randomly divided into two groups：treatment group，treatment group and control Group Three.In the control group，patients were treated with conventional methods，and the treatment group was treated in control group， and the small doses of dexamethasone were administered immediately from the initial admission，and the second group was treated in the control group，and the small dosage of dexamethasone was injected when the condition was aggravated. The relief time of abdominal pain， the recovery time of serum (urine) amylase，the improvement of exudation and the average length of hospitalization were compared in three groups.Results Treatment of postoperative abdominal pain relief Time：Treatment of a group of (3.2±1.3) d，the therapy group was (30.8±1.9) d，the control group was (4.1±2.7) d，the time of the peripheral exudation of the pancreas was improved：the treatment group (7.1±2.5) d，the treatment group (8.2±3.7) d，the control group (10.3±3.2) d，the serum after treatment.Urine amylase recovery time：Treatment of a group of (5.2±1.8)d，treatment of Group One or two (6.2±1.5) d，control Group (4.2±2.7) d，average length of stay in one group (9.2±3.4) d，treatment of two groups (10.8±3.9) D，control Group (13.6±4.9) d，showed that treatment of a group of patients significantly superior to other In both groups，the difference was statistically significant (p<0.05). In addition，the study showed that：treatment of a group of 44 cases of total cure，the results were 13 cases， effective 11 cases， invalid 2 cases，total effective number 68 cases，the efficiency was about 97.1%，treatment of the two groups were 25 cases，the effect was 19，effective 16 cases，invalid 10 cases，total effective number was 60，the total effective rate was 85.6%. Control group Cured 28 cases， 18 cases， effective 13 cases， invalid 11 cases，total effective number 59 cases，total effective rate 84.2%，it is better to treat a group of curative effect than control group，The difference was statistically significant (P<0.05)，and there was no statistically significant difference between the two treatment groups and the control group (P>0.05).Conclusion Low dose dexamethasone in early treatment of acute pancreatitis can reduce inflammation and improve therapeutic effect in patients with acute pancreatitis., http://www.100md.com(杜凡荣)