【摘要】目的 研究左氧氟沙星辅助抗结核治疗重症结核性脑膜炎临床疗效及对脑脊液指标的影响。方法 选取我院84例重症结核性脑膜炎患者，根据不同治疗方案分为观察组(n=44)和对照组(n=40)。对照组给予异烟肼+乙胺丁醇+吡嗪酰胺+利福平强化治疗。观察组在对照组治疗基础上，加用盐酸左氧氟沙星治疗。对比两组患者临床疗效及实验室指标变化。结果 观察组患者治疗显效率、脑脊液指标明显优于对照组，差异有统计学意义(P<0.05)。结论 左氧氟沙星辅助抗结核可提高重症结核性脑膜炎患者临床疗效，且对脑脊液指标影响积极，值得推广。

    【关键词】左氧氟沙星;抗结核治疗;重症结核性脑膜炎;脑脊液

    【中图分类号】R529.3 【文献标识码】A 【文章编号】ISSN.2095.6681.2020.23..02

    【Abstract】Objective To study the clinical effect of levofloxacin in the treatment of severe tuberculous meningitis and its effect on cerebrospinal fluid.Methods 84 patients with severe tuberculous meningitis were divided into observation group(n=44)and control group(n=40).The control group was given isoniazid+ethambutol+pyrazinamide+rifampin intensive treatment.The observation group was treated with levofloxacin hydrochloride on the basis of the control group.The clinical effect and laboratory indexes of the two groups were compared.Results The effective rate and CSF index of the observation group were significantly higher than those of the control group(P<0.05).Conclusion Levofloxacin can improve the clinical effect of severe tuberculous meningitis ......