右美托咪定与咪达唑仑对机械通气患者镇静效果的临床观察(2)
總之,在ICU机械通气患者镇静治疗中,右美托咪定与临床常用的镇静药物咪达唑仑相比,其镇静效果更具有优势,疗效及安全性更可靠,因其镇静满意度高,且具有镇痛、抗焦虑及对呼吸无抑制等持点,逐渐成为ICU临床医师的一线选择[14],为促进患者康复提供一个重要的保障。
参考文献
Dutta S,Karol MD,Cohen T,et a1.Effect of dexmedetomine on propofol requirements in healthy subjects.J Pharm Sci,2009,90(2):244-254.
Beloeil H,Corsia G,Coriat P,et al. Remifentanil compared with sufentanil during extra-corporeal shock wave lithotripsy spontaneous ventilation:a double-blind,randomized study [J]. Br J Anaesth,2002,89(4):567-570.
RR.Riker;Yahya Shehabi;Paula M.Bokesch;et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial.JAMA,2009,301(5):489-499.
Pandharipande P,Jackson J,Ely EW .Delirium:acute cognitive dysfunction in the critically ill[J].Curt Opin Crit Care,2005,11(2):360-368.
Frontera JA.Delirium and sedation in the ICU.NeurocritCare,2011,14(3):463-474.
V?litalo PA,Ahtola-S?til? T,Wighton A,et a1.Population Pharmacokinetics of Dexmedetomidine in Critically Ill Patients[J].Clin Drug Investig,2013,33(8):579-587.
Barr J,Fraser GL,Puntillo K,et a1.Clinical practice guidelines for the management of pain,agitation,and delirium in adult patients in the intensive care unit[J].Crical Care Medicine,2013.41(1):263-306.
右美托咪定临床应用指导意见(2013),中华医学会麻醉学分会
张学如.右美托咪啶在肺性脑病行无创辅助通气治疗中的应用临床肺科杂志,2013,18(12):2212-2213.
Steppan J,Wagner T.Central sympatholytics prolong survival in experimental sepsis.Crit Care,2009,13(1):R1 1.
Eren G,Cukurova Z,Demir G,et a1.Comparison of dexmedetomidine and three different doses of midazolam in preoperative sedation.J Anaesthesiology Clinical Pharmacology,2011,27(3):367-372.
Ryu JH,Lee SW,Lee JH,et a1.Randomized double-blind study of remifentanil and dexmedetomidine for flexible bronchoscopy.Br J Anaesth,2012,108(3):503-511.
Riker RR,Shehabi Y,Bokesch PM,et a1.Dexmedetomidine vs midazolam for sedation of critically ill patients[J].JAMA,2009,301(5):489-499.
Pichot C,Ghignone M,Quintin L Dexmedetomidine and clonidine:from second-to first-line sedative agents in the critical care setting?[J] Intensive Care Med,2011,27(4):219-237., http://www.100md.com(杨祎 王莹莹)
参考文献
Dutta S,Karol MD,Cohen T,et a1.Effect of dexmedetomine on propofol requirements in healthy subjects.J Pharm Sci,2009,90(2):244-254.
Beloeil H,Corsia G,Coriat P,et al. Remifentanil compared with sufentanil during extra-corporeal shock wave lithotripsy spontaneous ventilation:a double-blind,randomized study [J]. Br J Anaesth,2002,89(4):567-570.
RR.Riker;Yahya Shehabi;Paula M.Bokesch;et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial.JAMA,2009,301(5):489-499.
Pandharipande P,Jackson J,Ely EW .Delirium:acute cognitive dysfunction in the critically ill[J].Curt Opin Crit Care,2005,11(2):360-368.
Frontera JA.Delirium and sedation in the ICU.NeurocritCare,2011,14(3):463-474.
V?litalo PA,Ahtola-S?til? T,Wighton A,et a1.Population Pharmacokinetics of Dexmedetomidine in Critically Ill Patients[J].Clin Drug Investig,2013,33(8):579-587.
Barr J,Fraser GL,Puntillo K,et a1.Clinical practice guidelines for the management of pain,agitation,and delirium in adult patients in the intensive care unit[J].Crical Care Medicine,2013.41(1):263-306.
右美托咪定临床应用指导意见(2013),中华医学会麻醉学分会
张学如.右美托咪啶在肺性脑病行无创辅助通气治疗中的应用临床肺科杂志,2013,18(12):2212-2213.
Steppan J,Wagner T.Central sympatholytics prolong survival in experimental sepsis.Crit Care,2009,13(1):R1 1.
Eren G,Cukurova Z,Demir G,et a1.Comparison of dexmedetomidine and three different doses of midazolam in preoperative sedation.J Anaesthesiology Clinical Pharmacology,2011,27(3):367-372.
Ryu JH,Lee SW,Lee JH,et a1.Randomized double-blind study of remifentanil and dexmedetomidine for flexible bronchoscopy.Br J Anaesth,2012,108(3):503-511.
Riker RR,Shehabi Y,Bokesch PM,et a1.Dexmedetomidine vs midazolam for sedation of critically ill patients[J].JAMA,2009,301(5):489-499.
Pichot C,Ghignone M,Quintin L Dexmedetomidine and clonidine:from second-to first-line sedative agents in the critical care setting?[J] Intensive Care Med,2011,27(4):219-237., http://www.100md.com(杨祎 王莹莹)