曲唑酮对老年痴呆睡眠障碍患者睡眠状态 改善的效果观察(1)
摘要 目的：观察曲唑酮对老年痴呆睡眠障碍患者睡眠状态的改善作用。方法：选取2016年10月至2017年10月福建省老年医院神经内科收治的老年痴呆睡眠障碍患者90例，随机分为观察组和对照组，每组45例。对照组患者以阿普唑仑口服，观察组患者以曲唑酮口服。采用PSQI量表评估2组患者治疗前后的睡眠状态。结果：观察组患者治疗后1周及3周的睡眠改善总有效率为77.78%及91.11%，显著高于对照组的55.56%及73.33%( P <0.05)，秩和检验显示，PSQI量表评估结果也显著优于对照组( P <0.05)。结论：曲唑酮有助于老年痴呆睡眠障碍患者的睡眠状态改善，临床应用价值较高。
关键词 曲唑酮;老年痴呆;睡眠障碍;改善作用
中图分类号：R749.1+6 文献标识码：A doi： 10.3969/j.issn.2095-7130.2018.10.004
Observation on the Improvement Role of Trazodone for the Sleep State of Elderly Patients with Alzheimer′s Disease Complicated with Sleep Disorder
Lin Xiaojuan
(Department of Neurology，Geriatric Hospital of Fujian Province，Fuzhou，350009)
Abstract Objective： To observe the improvement role of trazodone for the sleep state of elderly patients with Alzheimer′s disease complicated with sleep disorder. Methods： A total of 90 elderly patients with Alzheimer′s disease complicated with sleep disorder in Geriatric Hospital of Fujian Province from October 2016 to October 2017 were divided into two groups according to the method of random distribution.45 patients of control group were treated with alprazolam by oral，45 patients of observation group were treated with trazodone by oral.And the sleep state of two groups before and after the treatment were evaluated with PSQI scale. Results： The total sleep improvement rates of observation group at 1st and 3rd week after the treatment were 77.78% and 91.11%，they were both higher than 55.56% and 73.33%of control group( P <0.05)，the rank-sum test showed，the PSQI scale evaluation results were significantly better than those of control group( P <0.05). Conclusion： The trazodone is helpful to the improvement of sleep state of elderly patients with Alzheimer′s disease complicated with sleep disorder，and its clinical application value is higher.
Key Words Trazodone;Elderly patients with Alzheimer′s disease;Sleep disorder;Improvement role
老年癡呆是发生在老年期及老年前期的一种原发性退行性脑病，是一种持续性高级神经功能活动障碍，即在没有意识障碍的状态下，记忆、思维、分析判断、视空间辨认、情绪等方面的障碍。患者的临床表现较多，其中以睡眠障碍表现也较常见，而睡眠障碍的存在对老年痴呆状态的不良影响较大，不利于疾病的改善，在对此类患者进行治疗时，睡眠障碍的改善也是疾病改善的一个重要方面。临床中关于此病患者的治疗研究较多[1-2]，其中以曲唑酮改善患者睡眠状态的研究多见，但是细致程度方面的研究相对欠缺。本研究就曲唑酮对老年痴呆睡眠障碍患者睡眠状态的改善作用进行观察，现报道如下。
1 资料与方法
1.1 一般资料 选取2016年10月至2017年10 月我院收治的老年痴呆睡眠障碍患者90例，随机分为观察组和对照组，每组45例。2组患者基本个人情况与痴呆程度等疾病情况比较，差异无统计学意义( P >0.05)，具有可比性。2组的基线资料数据比较。见表1。
1.2 纳入标准 1)年龄≥60岁者;2)符合老年痴呆的诊断;3)睡眠障碍者。
1.3 排除标准 1)其他精神疾病者;2)有其他严重疾病者;4) 1周内进行其他睡眠及痴呆治疗者;3)患者家属对研究不知情或未同意者。, 百拇医药(林小娟)
关键词 曲唑酮;老年痴呆;睡眠障碍;改善作用
中图分类号：R749.1+6 文献标识码：A doi： 10.3969/j.issn.2095-7130.2018.10.004
Observation on the Improvement Role of Trazodone for the Sleep State of Elderly Patients with Alzheimer′s Disease Complicated with Sleep Disorder
Lin Xiaojuan
(Department of Neurology，Geriatric Hospital of Fujian Province，Fuzhou，350009)
Abstract Objective： To observe the improvement role of trazodone for the sleep state of elderly patients with Alzheimer′s disease complicated with sleep disorder. Methods： A total of 90 elderly patients with Alzheimer′s disease complicated with sleep disorder in Geriatric Hospital of Fujian Province from October 2016 to October 2017 were divided into two groups according to the method of random distribution.45 patients of control group were treated with alprazolam by oral，45 patients of observation group were treated with trazodone by oral.And the sleep state of two groups before and after the treatment were evaluated with PSQI scale. Results： The total sleep improvement rates of observation group at 1st and 3rd week after the treatment were 77.78% and 91.11%，they were both higher than 55.56% and 73.33%of control group( P <0.05)，the rank-sum test showed，the PSQI scale evaluation results were significantly better than those of control group( P <0.05). Conclusion： The trazodone is helpful to the improvement of sleep state of elderly patients with Alzheimer′s disease complicated with sleep disorder，and its clinical application value is higher.
Key Words Trazodone;Elderly patients with Alzheimer′s disease;Sleep disorder;Improvement role
老年癡呆是发生在老年期及老年前期的一种原发性退行性脑病，是一种持续性高级神经功能活动障碍，即在没有意识障碍的状态下，记忆、思维、分析判断、视空间辨认、情绪等方面的障碍。患者的临床表现较多，其中以睡眠障碍表现也较常见，而睡眠障碍的存在对老年痴呆状态的不良影响较大，不利于疾病的改善，在对此类患者进行治疗时，睡眠障碍的改善也是疾病改善的一个重要方面。临床中关于此病患者的治疗研究较多[1-2]，其中以曲唑酮改善患者睡眠状态的研究多见，但是细致程度方面的研究相对欠缺。本研究就曲唑酮对老年痴呆睡眠障碍患者睡眠状态的改善作用进行观察，现报道如下。
1 资料与方法
1.1 一般资料 选取2016年10月至2017年10 月我院收治的老年痴呆睡眠障碍患者90例，随机分为观察组和对照组，每组45例。2组患者基本个人情况与痴呆程度等疾病情况比较，差异无统计学意义( P >0.05)，具有可比性。2组的基线资料数据比较。见表1。
1.2 纳入标准 1)年龄≥60岁者;2)符合老年痴呆的诊断;3)睡眠障碍者。
1.3 排除标准 1)其他精神疾病者;2)有其他严重疾病者;4) 1周内进行其他睡眠及痴呆治疗者;3)患者家属对研究不知情或未同意者。, 百拇医药(林小娟)
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