摘要 目的：探讨帕罗西汀联合奥氮平治疗对抑郁症患者抑郁程度及睡眠质量的影响。方法：选取2018年1月至12月期间淄博市精神卫生中心收治的抑郁症患者86例作为研究对象，利用随机数字表随机分为观察组与对照组，每组43例。对照组给予帕罗西汀治疗，观察组给予帕罗西汀联合奥氮平治疗。治疗12周后，比较2组患者抑郁程度及睡眠情况。结果：观察组HAMD评分(13.43±2.86)分，明显低于对照组(P<0.05);入睡时间(14.86±1.25)min、睡眠时长(6.73±1.35)h、深睡眠时间(4.36±0.78)h，与对照组比较差异有统计学意义(P<0.05)。结论：帕罗西汀联合奥氮平治疗可有效改善抑郁症患者的抑郁程度及睡眠质量。

    关键词 抑郁症;帕罗西汀;奥氮平;抑郁;睡眠质量

    Abstract Objective：To investigate the effects of paroxetine combined with olanzapine on depression and sleep quality in patients with depression.Methods：A Total of 86 patients with depression were randomly divided into treatment group and control group with 43 cases in each group.The control group was treated with paroxetine ......