阻塞性睡眠呼吸暂停综合征并胃食管反流病的分析及研究(1)

http://www.100md.com 2019年10月1日 《世界睡眠医学杂志》 201910

     摘要 目的：对阻塞性睡眠呼吸暂停综合征并胃食管反流病的影响因素因素进行分析研究。方法：选取2016年12月至2018年12月福建医科大学附属龙岩第一医院收治的睡眠呼吸暂停综合征并胃食管反流病患者123例作为研究对象，按照是否具有胃食管反流病分为观察组(n=41)和对照组(n=82)。观察组为阻塞性睡眠呼吸暂停综合征并胃食管反流病的患者，对照组为单纯阻塞性睡眠呼吸暂停综合征患者，统计2组患者的睡眠呼吸紊乱指数和体质脂肪健康指数，比较统计结果。结果：阻塞性睡眠呼吸暂停综合征并胃食管反流病的患者上述指标均比单纯阻塞性睡眠呼吸暂停综合征患者的高。结论：胃食管反流病和阻塞性睡眠呼吸暂停综合征密切相关。阻塞性睡眠呼吸暂停综合征并胃食管反流病的患者的临床症状表现和睡眠呼吸的紊乱指数明显高于单纯阻塞性睡眠呼吸暂停综合征的患者，单纯睡眠呼吸暂停综合征患者上述指标直接影响是否有胃食管反流合症。

    关键词 阻塞性睡眠呼吸暂停综合征;胃食管反流病;睡眠呼吸素乱指数;体质脂肪健康指数

    Abstract Objective：To analyze the influencing factors of obstructive sleep apnea syndrome and gastroesophageal reflux disease.Methods：A total of 123 patients with sleep apnea syndrome and gastroesophageal reflux disease admitted to our hospital from December 2016 to December 2018 were selected as the study object.According to whether they have gastroesophageal reflux disease，they were divided into the observation group(n=41)and the control group(n=82).The observation group was the patients with obstructive sleep apnea syndrome and gastroesophageal reflux disease，while the control group was the patients with simple obstructive sleep apnea syndrome.The sleep respiratory disorder index and body fat health index of the two groups were statistically analyzed and compared.Results：The above indexes were higher in patients with obstructive sleep apnea syndrome and gastroesophageal reflux disease than in patients with obstructive sleep apnea syndrome alone.Conclusion：Gastroesophageal reflux disease is closely related to obstructive sleep apnea syndrome.The clinical symptoms and disordered index of sleep breathing in patients with obstructive sleep apnea syndrome and gastroesophageal reflux disease are significantly higher than those with obstructive sleep apnea syndrome alone，and the above indexes directly affect whether there is gastroesophageal reflux disease in patients with sleep apnea syndrome alone.

    Key Words Obstructive sleep apnea syndrome;Gastroesophageal reflux disease;Sleep apnea disorder index;Body fat health index

    中图分类号：R56;R571 文献标识码：A doi：10.3969/j.issn.2095-7130.2019.10.057

    阻塞性睡眠呼吸暂停综合征，是一种严重影响生命质量、能够引发多种并发症的疾病，它是由上气道狭窄或阻塞引起的睡眠中多次呼吸暂停的疾病。胃食管反流病就是阻塞性睡眠呼吸暂停综合征的常见合症之一，胃食管反流病是指胃十二指肠中过多的内容物反流进入食管，从而引起患者胸痛，烧心，反酸和反食等症状，严重者可以产生炎性反应或者损伤食管外组织[1]。胃内容物的反流容易引发其他并发症或者引起患者不适感，其致病机理是阻塞性睡眠呼吸暂停综合征患者多为呼吸道阻塞症状，呼吸道阻塞致使负压升高，且呼吸暂停后连续吸气导致横膈压力增强，胸腔压力减弱，引发胃食管返流病或者使其加重。本文就是分析研究阻塞性睡眠呼吸暂停综合征并胃食管反流病的原因，现将结果报道如下。

    1 资料与方法

    1.1 一般资料 选取2016年12月至2018年12月福建医科大学附属龙岩第一医院收治的睡眠呼吸暂停综合征并胃食管反流病患者123例作为研究对象，按照是否具有胃食管反流病分为观察组(n=41)和对照组(n=82)。观察组中男36例，女5例，平均年龄54.5岁。对照组中男70例，女12例，平均年龄55.2岁。2组患者一般资料经比较，差异无统計学意义(P>0.05)，具有可比性。, http://www.100md.com(李友堂 苏霞 罗马长)

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