美罗华联合CHOP方案治疗弥漫性大B细胞淋巴瘤患者中的应用研究及护理(1)
【摘 要】 目的：探析在彌漫性大B细胞淋巴瘤病人的护理干预中予以CHOP方案与美罗华联合治疗的临床效果。方法：入选本院2016年6月至2017年5月收治的70例弥漫性大B细胞淋巴瘤病人，根据随机数字表法分为研究组、对照组，每组35例，两组均进行美罗华联合CHOP方案疗法，每21d为一个治疗周期，治疗6个周期，研究组实施持续质量改进(CQI)护理模式，对照组进行基础护理，比较两组的近期临床效果、用药后不良反应发生情况、护理满意度及依从性，以及护理前后生活质量变化。结果：研究组的近期临床有效率为82.9%，对照组的近期临床有效率为60.0%，两组比较差异有统计学意义(P<0.05)；研究组用药后发生带状疱疹、转氨酶升高、发热畏寒、骨髓抑制、贫血、消化道不适、白细胞降低等不良反应显著低于对照组，差异有统计学意义(P<0.05)；研究组的护理满意率、护理依从性分别为77.1%、91.4%，对照组的护理满意率、护理依从性分别为62.9%、65.7%，两组比较差异有统计学意义(P<0.05)。两组护理后生活质量评分中食欲、睡眠、精神状态、疲乏以及日常活动等指标均优于护理前，其中研究组各项生活质量评分均优于对照组，差异对比具有统计学意义(P<0.05)。结论：弥漫性大B细胞淋巴瘤病人进行美罗华联合CHOP方案疗法，全程予以干预性护理，临床效果确切，可显著延长病人的生存期，降低用药后不良反应发生率，提高护理依从性及满意度。
【关键词】 弥漫性大B细胞淋巴瘤；CHOP方案；美罗华；护理干预；临床观察
The application and effect of nursing intervention in patients with diffuse large B cell lymphoma treated with rituximab combined with CHOP regimen
Nie Yanhong
Shandong Province Blood Department， Heze City Hospital， Heze，Shandong 274000
[Abstract] Objective：To explore the application and effect of nursing intervention in patients with diffuse large B cell lymphoma treated with rituximab combined with CHOP regimen. Methods：70 diffuse large B cell lymphoma patients were selected in our hospital from June 2016 to May 2017， according to randomly divided into study group and control group， 35 cases in each group， two groups were given rituximab in combination with chop regimen， every 21 days for a treatment cycle for six cycles of treatment，the study group carried out the nursing mode of continuous quality improvement(CQI)，the control group carried out basic nursing，compared the recent clinical effect，the occurrence of adverse reaction after medication，the satisfaction and compliance of the two groups，and the quality of life before and after nursing.Results： The shortterm clinical effective rate in study group was 82.9%， control group was 60.0%， there was significant difference between two groups (P<0.05)；the adverse reactions of herpes zoster，aminotransferase， fever and chilling，myelosuppression，anemia，digestive tract discomfort and leukocyte reduction were significantly lower in the study group than in the control group，with a significant difference(P<0.05).The nursing satisfaction rate and nursing compliance of the study group were 77.1% and 91.4% respectively，the nursing satisfaction rate and nursing compliance in the control group were 62.9% and 65.7% respectively，there were significant differences in the two groups (P<0.05).The indexes of appetite，sleep，mental state，fatigue and daily activity in the quality of life score of the two groups were superior to those before nursing，and the scores of the quality of life of the study group were all better than those in the control group，and the difference was statistically significant(P<0.05).Conclusion： Diffuse large B cell lymphoma patients rituximab in combination with chop regimen， whole be intervention nursing， have clinical curative effect， can significantly prolong the survival time of the patients， reduce the drug adverse reactions， and improve the compliance of nursing and satisfaction., 百拇医药(聂艳红)
【关键词】 弥漫性大B细胞淋巴瘤；CHOP方案；美罗华；护理干预；临床观察
The application and effect of nursing intervention in patients with diffuse large B cell lymphoma treated with rituximab combined with CHOP regimen
Nie Yanhong
Shandong Province Blood Department， Heze City Hospital， Heze，Shandong 274000
[Abstract] Objective：To explore the application and effect of nursing intervention in patients with diffuse large B cell lymphoma treated with rituximab combined with CHOP regimen. Methods：70 diffuse large B cell lymphoma patients were selected in our hospital from June 2016 to May 2017， according to randomly divided into study group and control group， 35 cases in each group， two groups were given rituximab in combination with chop regimen， every 21 days for a treatment cycle for six cycles of treatment，the study group carried out the nursing mode of continuous quality improvement(CQI)，the control group carried out basic nursing，compared the recent clinical effect，the occurrence of adverse reaction after medication，the satisfaction and compliance of the two groups，and the quality of life before and after nursing.Results： The shortterm clinical effective rate in study group was 82.9%， control group was 60.0%， there was significant difference between two groups (P<0.05)；the adverse reactions of herpes zoster，aminotransferase， fever and chilling，myelosuppression，anemia，digestive tract discomfort and leukocyte reduction were significantly lower in the study group than in the control group，with a significant difference(P<0.05).The nursing satisfaction rate and nursing compliance of the study group were 77.1% and 91.4% respectively，the nursing satisfaction rate and nursing compliance in the control group were 62.9% and 65.7% respectively，there were significant differences in the two groups (P<0.05).The indexes of appetite，sleep，mental state，fatigue and daily activity in the quality of life score of the two groups were superior to those before nursing，and the scores of the quality of life of the study group were all better than those in the control group，and the difference was statistically significant(P<0.05).Conclusion： Diffuse large B cell lymphoma patients rituximab in combination with chop regimen， whole be intervention nursing， have clinical curative effect， can significantly prolong the survival time of the patients， reduce the drug adverse reactions， and improve the compliance of nursing and satisfaction., 百拇医药(聂艳红)
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