Th22细胞及其细胞因子与不明原因复发性流产的关系研究(4)
綜上所述，Th22细胞的数量及其效应因子IL-22浓度的显著增高可能与URSA具有一定相关性，同时Th22细胞与Th17细胞呈相关，提示两种细胞的分化成熟，可能相互影响，具有共同的驱动方式。此外，在URSA中，IL-22可能同时来源于Th22细胞和Th17细胞，但究竟IL-22是如何发挥作用的，以及其与两种细胞之间的潜在关系，仍需要深入探究。
参考文献
[1] Sierra S，Stephenson M.Genetics of recurrent pregnancy loss[J].Semin Reprod Med，2006，24(01)：17-24.
[2] El Hachem H，Crepaux V，May-Panloup P，et al.Recurrent pregnancy loss：current perspectives[J].Int J Womens Health，2017，(09)：331-345.
, http://www.100md.com
[3] Kutteh W H.Novel strategies for the management of recurrent pregnancy loss[J].Semin Reprod Med，2015，33(03)：161-168.
[4] Qian J，Zhang N，Lin J，et al.Distinct pattern of Th17/Treg cells in pregnant women with a history of unexplained recurrent spontaneous abortion[J].Biosci Trends，2018，12(02)：157-167.
[5] Zhao X，Jiang Y，Wang L，et al.Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion[J].Geburtshilfe Frauenheilkd，2018，78(07)：677-683.
, 百拇医药
[6] Annunziato F，Romagnani S.Heterogeneity of human effector CD4+ T cells[J].Arthritis Res Ther，2009，11(06)：257.
[7] Lee S，Kim J，Hur S，et al.An imbalance in interleukin-17-producing T and Foxp3(+) regulatory T cells in women with idiopathic recurrent pregnancy loss[J].Hum Reprod，2011，26(11)：2964-2971.
[8] Raghupathy R，Makhseed M，Azizieh F，et al.Maternal Th1-and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions[J].Cell Immunol，1999，196(02)：122-130.
, http://www.100md.com
[9] Trifari S，Kaplan C，Tran E，et al.Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17，T(H)1 and T(H)2 cells[J].Nat Immunol，2009，10(08)：864-871.
[10]Fujita H.The role of IL-22 and Th22 cells in human skin diseases[J].J Dermatol Sci，2013，72(01)：3-8.
[11]Tian T，Yu S，Ma D.Th22 and related cytokines in inflammatory and autoimmune diseases[J].Expert Opin Ther Targets，2013，17(02)：113-125.
, 百拇医药
[12]Kwak-Kim J，Bao S，Lee S，et al.Immunological modes of pregnancy loss：inflammation， immune effectors，and stress[J].Am J Reprod Immunol，2014，72(02)：129-140.
[13]Jaslow C，Carney J，Kutteh W.Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses[J].Fertil Steril，2010，93(04)：1234-1243.
[14]Wu L，Luo L，Zhang Y，et al.Alteration of Th17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyte immunization therapy[J].Reprod Biol Endocrinol，2014，12：74., http://www.100md.com(李松磊 李倩如)
参考文献
[1] Sierra S，Stephenson M.Genetics of recurrent pregnancy loss[J].Semin Reprod Med，2006，24(01)：17-24.
[2] El Hachem H，Crepaux V，May-Panloup P，et al.Recurrent pregnancy loss：current perspectives[J].Int J Womens Health，2017，(09)：331-345.
, http://www.100md.com
[3] Kutteh W H.Novel strategies for the management of recurrent pregnancy loss[J].Semin Reprod Med，2015，33(03)：161-168.
[4] Qian J，Zhang N，Lin J，et al.Distinct pattern of Th17/Treg cells in pregnant women with a history of unexplained recurrent spontaneous abortion[J].Biosci Trends，2018，12(02)：157-167.
[5] Zhao X，Jiang Y，Wang L，et al.Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion[J].Geburtshilfe Frauenheilkd，2018，78(07)：677-683.
, 百拇医药
[6] Annunziato F，Romagnani S.Heterogeneity of human effector CD4+ T cells[J].Arthritis Res Ther，2009，11(06)：257.
[7] Lee S，Kim J，Hur S，et al.An imbalance in interleukin-17-producing T and Foxp3(+) regulatory T cells in women with idiopathic recurrent pregnancy loss[J].Hum Reprod，2011，26(11)：2964-2971.
[8] Raghupathy R，Makhseed M，Azizieh F，et al.Maternal Th1-and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions[J].Cell Immunol，1999，196(02)：122-130.
, http://www.100md.com
[9] Trifari S，Kaplan C，Tran E，et al.Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17，T(H)1 and T(H)2 cells[J].Nat Immunol，2009，10(08)：864-871.
[10]Fujita H.The role of IL-22 and Th22 cells in human skin diseases[J].J Dermatol Sci，2013，72(01)：3-8.
[11]Tian T，Yu S，Ma D.Th22 and related cytokines in inflammatory and autoimmune diseases[J].Expert Opin Ther Targets，2013，17(02)：113-125.
, 百拇医药
[12]Kwak-Kim J，Bao S，Lee S，et al.Immunological modes of pregnancy loss：inflammation， immune effectors，and stress[J].Am J Reprod Immunol，2014，72(02)：129-140.
[13]Jaslow C，Carney J，Kutteh W.Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses[J].Fertil Steril，2010，93(04)：1234-1243.
[14]Wu L，Luo L，Zhang Y，et al.Alteration of Th17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyte immunization therapy[J].Reprod Biol Endocrinol，2014，12：74., http://www.100md.com(李松磊 李倩如)