【摘 要】 目的：研究帕利哌酮缓释片+丁螺环酮治疗难治性精神分裂症患者的疗效。方法：选难治性精神分裂症患者72例，随机分组治疗，对照组采用帕利哌酮缓释片治疗;研究组服用帕利哌酮缓释片结合丁螺环酮治疗。比较临床疗效。结果：研究组治疗总有效率、PANSS總分、不良反应率均显著优于对照组，差异显著(P<0.05)。两组阴阳因子的总分减分率，研究组和对照组相似，P>0.05。结论：将帕利哌酮缓释片+丁螺环酮用于难治性精神分裂症患者中，其疗效提高，安全性提高，可用于临床用药。

    【关键词】 帕利哌酮缓释片;丁螺环酮;难治性精神分裂症

    文章编号：WHR201910228

    [Abstract] Objective：To study the efficacy of paliperidone sustained-release tablets+buspirone in the treatment of patients with refractory schizophrenia. Methods： 72 patients with refractory schizophrenia were randomly divided into two groups： the control group was treated with paliperidone sustained-release tablets. The research group was treated with paliperidone sustained-release tablets combined with buspirone. Compare clinical efficacy. Results： The total effective rate ......