利培酮、阿立哌唑和氯氮平治疗精神分裂症患者的临床效果比较(1)
【摘 要】 目的：分析利培酮、阿立哌唑以及氯氮平治疗精神分裂症患者的临床效果。方法：选取本院2017年9月至2018年12月收治的138例精神分裂症患者作为研究对象，根据治疗药物的不同将其分为A组、B组和C组，每组各有患者46例，A组患者采用利培酮治疗，B组患者采用阿立哌唑治疗，C组患者采用氯氮平治疗。比较三组患者的临床治疗有效率和治疗前后血糖、体质量指数。结果：A、B、C三组患者的临床治疗有效率分别为93.48%、97.83%、84.78%，B组患者明显高于其他两组，表明统计学差异显著(P<0.05);而且三组患者治疗前血糖和体质量指数对比差异并无统计学意义(P>0.05)，治疗后B组各水平明显低于其他两组，差异具有统计学意义(P<0.05)。结论：精神分裂症患者采取利培酮、阿立哌唑和氯氮平治疗均能取得显著的疗效，但相比之下能够发现，阿立哌唑治疗效果最佳而且对于糖脂代谢的影响最小。
【关键词】 精神分裂症;利培酮;阿立哌唑;氯氮平;临床效果
Comparison of clinical effects of risperidone， aripiprazole and clozapine in the treatment of schizophrenia
, 百拇医药
Zhang Yan
Department of Psychiatry， Changchun Psychological Hospital， Changchun， Jilin 130062
[Abstract] Objective：To analyze the clinical effect of risperidone， aripiprazole and clozapine in the treatment of schizophrenia. Methods： 138 schizophrenic patients in our hospital from September 2017 to December 2018 were selected as the analysis objects， and they were divided into group A， group B and group C according to different treatment drugs， with 46 patients in each group. Patients in group A were treated with risperidone， patients in group B were treated with aripiprazole， and patients in group C were treated with clozapine. Before and after treatment， the blood glucose index and clinical effective rate of the three groups were compared. Results： The clinical effective rates of group A， group B and group C were 93.48%， 97.83% and 84.78%， respectively. The patients in group B were significantly higher than those in the other two groups， and the differences were statistically significant (P<0.05). Moreover， there was no significant difference in blood glucose and body mass index among the three groups before treatment (P>0.05)， After treatment， the levels in group B were significantly lower than those in the other two groups (P<0.05). Conclusion： Risperidone， aripiprazole and clozapine can achieve significant curative effect in schizophrenic patients， but it can be found that aripiprazole has the best effect and the least effect on glucose and lipid metabolism.
, 百拇医药
[Key words]Schizophrenia; Risperidone; Aripiprazole; Clozapine; Clinical effect
精神分裂癥是临床常见精神类疾病，在所有精神类疾病中它的患病率最高。该病属于慢性疾病，若不及时治疗将严重危害患者的身心健康，甚至会给患者的家庭带来沉重的负担。临床中目前治疗该病多采用非典型抗精神病药物治疗，而且这种药物的疗效已经得到了国内外的广泛认可，但是临床发现[1]，患者在服用药物期间明显出现体质量的变化以及糖脂代谢异常的情况，这两种不良反应也是业界医学者重点关心的问题。由于利培酮、阿立哌唑以及氯氮平是临床常见治疗精神分裂症的药物，因此本文将本院收治的138例精神分裂症患者作为研究对象，分析三种药物治疗精神分裂症的临床效果，现将具体结果汇报如下。
1 资料与方法
1.1 基本资料
将本院2017年9月至2018年12月收治的138例精神分裂症患者作为研究对象，根据不同的治疗方式将其分为A、B、C三组，所有患者经过诊断均确诊为精神分裂症，符合临床诊断标准，本次研究经过本院医学伦理委员会批准，所有患者均签订知情同意书，自愿参与本研究。对比三组患者的基本资料后显示差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(张焱)
【关键词】 精神分裂症;利培酮;阿立哌唑;氯氮平;临床效果
Comparison of clinical effects of risperidone， aripiprazole and clozapine in the treatment of schizophrenia
, 百拇医药
Zhang Yan
Department of Psychiatry， Changchun Psychological Hospital， Changchun， Jilin 130062
[Abstract] Objective：To analyze the clinical effect of risperidone， aripiprazole and clozapine in the treatment of schizophrenia. Methods： 138 schizophrenic patients in our hospital from September 2017 to December 2018 were selected as the analysis objects， and they were divided into group A， group B and group C according to different treatment drugs， with 46 patients in each group. Patients in group A were treated with risperidone， patients in group B were treated with aripiprazole， and patients in group C were treated with clozapine. Before and after treatment， the blood glucose index and clinical effective rate of the three groups were compared. Results： The clinical effective rates of group A， group B and group C were 93.48%， 97.83% and 84.78%， respectively. The patients in group B were significantly higher than those in the other two groups， and the differences were statistically significant (P<0.05). Moreover， there was no significant difference in blood glucose and body mass index among the three groups before treatment (P>0.05)， After treatment， the levels in group B were significantly lower than those in the other two groups (P<0.05). Conclusion： Risperidone， aripiprazole and clozapine can achieve significant curative effect in schizophrenic patients， but it can be found that aripiprazole has the best effect and the least effect on glucose and lipid metabolism.
, 百拇医药
[Key words]Schizophrenia; Risperidone; Aripiprazole; Clozapine; Clinical effect
精神分裂癥是临床常见精神类疾病，在所有精神类疾病中它的患病率最高。该病属于慢性疾病，若不及时治疗将严重危害患者的身心健康，甚至会给患者的家庭带来沉重的负担。临床中目前治疗该病多采用非典型抗精神病药物治疗，而且这种药物的疗效已经得到了国内外的广泛认可，但是临床发现[1]，患者在服用药物期间明显出现体质量的变化以及糖脂代谢异常的情况，这两种不良反应也是业界医学者重点关心的问题。由于利培酮、阿立哌唑以及氯氮平是临床常见治疗精神分裂症的药物，因此本文将本院收治的138例精神分裂症患者作为研究对象，分析三种药物治疗精神分裂症的临床效果，现将具体结果汇报如下。
1 资料与方法
1.1 基本资料
将本院2017年9月至2018年12月收治的138例精神分裂症患者作为研究对象，根据不同的治疗方式将其分为A、B、C三组，所有患者经过诊断均确诊为精神分裂症，符合临床诊断标准，本次研究经过本院医学伦理委员会批准，所有患者均签订知情同意书，自愿参与本研究。对比三组患者的基本资料后显示差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(张焱)