【Summary】Accumulating evidence indicates that the Brain-derived neurotrophic pathway play important roles in depression.Previous studies in our laboratory have demonstrated that YLSPA produced antidepressant-like action in Kunming mice with various mouse models of behavioral despair (FST and TST). The present study aimed to examine whether YLSPA could affect the chronic unpredictable mild stress (CUMS)-induced depression in mice. The mechanism(s) underlying the antidepressant-like action was investigated by measuring brain-derived neurotrophic factor (BDNF) ......