【摘 要】目的：探讨人血清附睾蛋白4(HE4)和 人卵巢癌抗原(CA125)卵巢癌诊断中的应用价值。方法：收集78例卵巢癌患者和同期健康体检者的血清标本，用雅培化学发光分析仪分别检测各组的血清HE4和CA125水平。结果：卵巢癌患者的血清HE4和CA125水平明显高于对照组；血清HE4诊断卵巢癌的敏感度、特异性及准确度均比CA125高；血清HE4在卵巢癌患者的不同分期表达差异有统计学意义(p<0.05)；HE4和CA125联合检测可以提高卵巢癌诊断的敏感度、特异度及准确度。结论：HE4和CA125联合检测可以提高卵巢癌的诊断效率。

    【关键词】附睾蛋白4； CA125； 卵巢癌； 联合诊断

    Abstract： Objective To investigate the value of human serum epididymis protein 4 (HE4) and human ovarian cancer antigen (CA125) in the diagnosis of ovarian cancer. Methods Serum samples from 78 patients with ovarian cancer and healthy subjects were collected. The serum levels of HE4 and CA125 were measured by Abbott Chemiluminescence Analyzer. Results The levels of serum HE4 and CA125 in patients with ovarian cancer were significantly higher than those in the control group. The sensitivity ......