中国汉族高原肺水肿EPAS1基因多态性研究
杨应忠,韵海霞,王亚平,胥 瑾(青海大学医学院)
杨应忠(1977~),男,汉族,青海籍,副教授
中国汉族高原肺水肿EPAS1基因多态性研究
杨应忠,韵海霞,王亚平,胥瑾
(青海大学医学院)
摘要目的探讨EPAS1基因与高原肺水肿易感性的相关关系。方法选取135例HAPE患者,137例健康平原对照者,135例玉树藏族健康对照者。采用iMLDR技术对EPAS1基因的rs10193827、rs10206434、rs11675232、rs13006131、rs13419896、rs1562453、rs17035010、rs1868092、rs1992846、rs4953354、rs4953359、rs4953361、rs6544889、rs7571218、rs7589621、rs7598371多态性位点在三组样本中进行SNP分型。结果rs10193827、rs11675232、rs13419896、rs17035010、rs1992846、rs4953359、rs6544889、rs7589621、rs10206434、rs13006131、rs1562453、rs1868092、rs4953354、rs4953361、rs7571218、rs7598371的基因型CC、TT、GG、TT、TT、TT、AA、AA、GG、CC、CC、GG、AA、GG、AA、GG在汉族普遍,而与其对应的反向纯合子则在藏族中普遍,差异有显著性(P
Table 1 PCR primer sequences for EPAS1 SNPs genotyping
![](https://cimg.fx361.com/images/2023/0123/589e5c03325539a83c12268dcd55c0815d6780f6.webp)
Table 2 The probe sequence for EPAS1 SNPs genotyping.
Statisticalanalysis
Statistical analyses were performed using the SPSS software(version 17.0,SPSS,Inc,Chicago,USA).Categorical values were presented as number(n)and percentage(%).Hardy-Weinberg equilibrium as well as genotypes and alleles distributions between groups were tested by chi-square test.The odds ratio ......
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