白振忠综述，格日力审校

    (1.青海大学医学院青海-犹他高原医学联合重点实验室；2.青海大学高原医学研究中心)

    Introduction

    With the ringing bell of the 2019 Nobel prize，HIF-1α has stood in the center of the stage for the researching frontiers of oxygen sensing and hypoxia activation[1，2].Hemostasis of oxygen allows the survival of the cell in the most end of our body and populations standing in the highest sites of our planate[3].From sensing oxygen in cellularly to modulating in globally，it makes the fundamental requirements of the regular functions in human life，energy metabolisms[4].Considering the HIF-1α has orchestrated the rhythm of the symphony for both cancer[5，6]and high-altitude medicine research，together a broad genes involved metabolism has been modulated by HIF-1α，from enhanced lactate dehydratase LDH for lactate producing to increased glycolysis，and blocked pyruvate into Krebs Cycle as well as β-oxidation in lipids by shunt pyruvate dehydratase PDH，to inhibit the electric chain reactions ETCs for mitochondrial respiration.Metabolic reshaping is the major adaptation approaches in cellular strategy for hypoxia ......