陈永正，杨 敏，卓俊睿，郑代军，付少彬

    (遵义医学院药学院，贵州遵义 563099)

    1 Introduction

    Chiral sec-alcohols were key intermediate in the synthesis of fine chemicals，pharmaceuticals，and agrochemicals[1].Chiral benzhydrol was one kind of important building block for synthesis of orphenadrine 1，neobenodine 2，carbinoxamine 3[2].Moreover，chiral benzhydrol was also used as an intermediate of some potent anti-inflammatory drugs 4 and ODE-Ⅳ inhibitor.

    Currently，numerous syntheses of chiral benzhydrol mainly depended on reduction of ketones，hydrolysis of esters and kenetic resolution of racemic alcohols with chemical catalyst or biocatalyst[3].For example，a new γ - amino thiol was designed for synthesis of chiral benzhydrol by asymmetric arylation of aromatic aldehydes[4].The addition reaction of organoboronic acids with aldehydes catalyzed by CoI2/(R，R)-BDPP also give chiral benzhydrol in excellent yields with 90% ～ 99%ee[5-6].Truppo group reported that a reductase catalyzed the reduction of di- aryl ketones to produce chiral benzhydrol[7]. ......