杨 露，陈盼盼，罗 敏,2，高 杨，邓 江

    (1.遵义医科大学 基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室，贵州 遵义 563099;2.遵义市第一人民医院，贵州 遵义 563000)

    Pulmonary fibrosis is a chronic,progressive and a variety of diffuse interstitial lung diseases,with high morbidity and mortality rate[1-3].Most of Patients died of respiratory failure eventually and there is no effective treatment[4].Therefore,the disease is harmful to human health.Inflammation and immune response are one of the main pathogenesis of lung tissue injury and fibrosis.A large number of studies have shown that oxygen free radicals play an important role in inflammation and immune-mediated tissue damage[5].

    Total ginsenosides(TG)is the main active component of ginseng,which is one of the most precious traditional chinese medicinal herbs,and has been shown to exert beneficial pharmacology effects on the respiratory system[6-8].TG has been reported to inhibit acute lung injury[9-10].TG is effective in inhibiting oxidative and anti-inflammatory injury.At the same time,TG can regulate the immune function[11-13].However,it is unclear whether TG can inhibit pulmonary fibrosis.In this study,we observed the protective effect and mechanism of TG on pulmonary fibrosis induced by monocrotaline(MCT)and preliminarily determined whether it was related to antioxidant damage. ......