罗 超，李意奇，王俊逸，李叶丽，吕俊远，杨丹莉

    (1.遵义医科大学 基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室，贵州 遵义 563099；2.遵义医科大学珠海校区，广东 珠海 519041；3.遵义医科大学附属医院,贵州 遵义 563099)

    1 Introduction

    Percutaneous transluminal coronary angioplasty is now widely used in the treatment of obstructed atherosclerotic vessels.However,its overall benefits are limited by the fact that it may induce neointimal hyperplasia and restenosis after interventional surgery in many patients who are initially treated successfully[1-2].The evidences that transforming growth factor-beta1(TGF-β1)/Smads plays a key role in the development of neointimal hyperplasia and restenosis have been presented at the cellular,molecular,and genetic levels[3-4].

    Icariside II (ICS II) is one of active ingredient of Herba Epimedii,which has a variety of pharmacological effects,such as anti-inflammation,immune regulation,anti-tumor,protecting cardiovascular system and so on[5-7].However,it is not known whether ICSII has effects on neointimal hyperplasia and restenosis.In this study,we sought to determine the effects of ICSII on intimal hyperplasia in rat carotid arteries induced by balloon injury.We additionally explored whether the mechanism is relative to TGF-β1/Smads. ......