摘要：随着基因检测的普及，基因指导下个体化精准治疗成为进一步提高靶向治疗疗效的有效途径。培唑帕尼是一种多靶点酪氨酸激酶抑制剂，其疗效与不良反应的差异与相关基因多态性的关系日益受到关注。本文就培唑帕尼相关酶的基因多态性与其疗效及所致不良反应的关系进行综述。

    关键词：培唑帕尼;酪氨酸激酶抑制剂;基因多态性

    【中图分类号】R-0 【文献标识码】A 【文章编号】2107-2306(2020)01-156-02

    [Abstract] With the popularization of gene testing， personalized and precise treatment under the guidance of genes has become an effective way to further improve the efficacy of targeted therapy.Pazopanib is a multi-target tyrosine kinase inhibitor.In this paper ......