质谱技术在抗体药物分析中的应用(2)
参考文献：
[1]王兰，朱磊，徐刚领，等.单克隆抗体类生物治疗药物研究进展[J].中国药学杂志，2014，49(23)：2058-2064.
[2]李壮林，姚雪静. 单克隆抗体药物研究进展[J].药物生物技术，2014，21(5)：456-461.
[3]Austin CD，Wen X，Gazzard L，et al. Oxidizing potential of endosomes and lyosomes limits intracellular cleavage of disulfidebased antibody-drug conjugates[J]. Proc Natl Acad Sci，2005，102(50)：17987-17992.
[4]Kontenrmann，R. Dual targeting strategies with bispecific antibodies[J]. Mabs，2012，4(2)：182-197.
[5]Vestal M L，Juhasz P. Delayed extraction matrix-assisted laser desorption time-of-flight mass spectrometry.[J].Rapid Commun Mass Spectrom，1995，9：1044-1050
[6]Tisato F，Bolzati C，Porchia M.Contribution of electrospray mass spectrometry for characterization，design，and development of nitride technetium and rhenium heterocomplexes as potential radiopharmaceuticals[J]. Mass Spectrometry Reviews，Published Online，2004，23(5)：309-332.
[7]李萌，于傳飞，王馨，等. 相对分子质量测定作为单抗药物常规放行分析方法的可行性商榷[J]. 药物分析杂志，2015，12：2076-2082.
[8]Zhu L，Guo Q，Guo H，et al.Versatile characterization of glycosylation modification in CTLA4-Ig fusion proteins by liquid chromatography-mass spectrometry. [J]. MAbs. 2014；6(6)：1474-1485.
[9]于传飞，李萌，郭玮，等. 一种抗体药物偶联物中药物抗体偶联比的测定[J]. 药学学报，2014，03：363-367.
[10]Wakankar A Chen Y，Gokarn Y，et al. Analytical methods for physicochemical characterization of antibody drug conjugates. [J]. MAbs. 2011；3(2)：161-172.
[11]Duan X T，Dai L P，Chen S C，et al. Nano-scale liquid chromatography/mass spectrometry and on-the-fly orthogonal array optimization for quantification of therapeutic monoclonal antibodies and the application in preclinical analysis. [J]. J Chromatogr A，2012，1251(17)：63-73.
[12]Stackhouse N，Miller AK，Gadgil HS. A high-throughput UPLC method for the characterization of chemical modifications in monoclonal antibody molecules. [J].J Pharm Sci. 2011；100(12)：5115-5125.
作者简介：高燕波(1990～)，女，研究方向为抗体药物研发。正在攻读上海交通大学生物工程专业硕士；Email：gaoyanbo_1990@163.com, 百拇医药
[1]王兰，朱磊，徐刚领，等.单克隆抗体类生物治疗药物研究进展[J].中国药学杂志，2014，49(23)：2058-2064.
[2]李壮林，姚雪静. 单克隆抗体药物研究进展[J].药物生物技术，2014，21(5)：456-461.
[3]Austin CD，Wen X，Gazzard L，et al. Oxidizing potential of endosomes and lyosomes limits intracellular cleavage of disulfidebased antibody-drug conjugates[J]. Proc Natl Acad Sci，2005，102(50)：17987-17992.
[4]Kontenrmann，R. Dual targeting strategies with bispecific antibodies[J]. Mabs，2012，4(2)：182-197.
[5]Vestal M L，Juhasz P. Delayed extraction matrix-assisted laser desorption time-of-flight mass spectrometry.[J].Rapid Commun Mass Spectrom，1995，9：1044-1050
[6]Tisato F，Bolzati C，Porchia M.Contribution of electrospray mass spectrometry for characterization，design，and development of nitride technetium and rhenium heterocomplexes as potential radiopharmaceuticals[J]. Mass Spectrometry Reviews，Published Online，2004，23(5)：309-332.
[7]李萌，于傳飞，王馨，等. 相对分子质量测定作为单抗药物常规放行分析方法的可行性商榷[J]. 药物分析杂志，2015，12：2076-2082.
[8]Zhu L，Guo Q，Guo H，et al.Versatile characterization of glycosylation modification in CTLA4-Ig fusion proteins by liquid chromatography-mass spectrometry. [J]. MAbs. 2014；6(6)：1474-1485.
[9]于传飞，李萌，郭玮，等. 一种抗体药物偶联物中药物抗体偶联比的测定[J]. 药学学报，2014，03：363-367.
[10]Wakankar A Chen Y，Gokarn Y，et al. Analytical methods for physicochemical characterization of antibody drug conjugates. [J]. MAbs. 2011；3(2)：161-172.
[11]Duan X T，Dai L P，Chen S C，et al. Nano-scale liquid chromatography/mass spectrometry and on-the-fly orthogonal array optimization for quantification of therapeutic monoclonal antibodies and the application in preclinical analysis. [J]. J Chromatogr A，2012，1251(17)：63-73.
[12]Stackhouse N，Miller AK，Gadgil HS. A high-throughput UPLC method for the characterization of chemical modifications in monoclonal antibody molecules. [J].J Pharm Sci. 2011；100(12)：5115-5125.
作者简介：高燕波(1990～)，女，研究方向为抗体药物研发。正在攻读上海交通大学生物工程专业硕士；Email：gaoyanbo_1990@163.com, 百拇医药